Detailed information of TA system TA029358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1414359..1415962
• Replicon: chromosome
• Accession: NC_021066
• Organism: Raoultella ornithinolytica B6

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1Y6GHD8
• Locus tag: RORB6_RS06345
• Protein ID: WP_015584335.1
• Coordinates: 1414359..1415690 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: RORB6_RS06350
• Protein ID: WP_015584336.1
• Coordinates: 1415690..1415962 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RORB6_RS06330	1410233..1411147	-	915	WP_015584333.1	branched-chain amino acid ABC transporter permease	-
RORB6_RS06335	1411247..1412305	-	1059	WP_162180097.1	branched-chain amino acid ABC transporter substrate-binding protein	-
RORB6_RS06340	1413011..1414426	+	1416	WP_099144431.1	glycoside hydrolase family 10 protein	-
RORB6_RS06345	1414359..1415690	-	1332	WP_015584335.1	type II toxin-antitoxin system HipA family toxin	Toxin
RORB6_RS06350	1415690..1415962	-	273	WP_015584336.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
RORB6_RS06355	1416165..1416719	-	555	WP_015584337.1	RNA polymerase sigma factor	-
RORB6_RS06360	1416725..1417150	-	426	WP_032724724.1	hypothetical protein	-
RORB6_RS06365	1417284..1418237	-	954	WP_004861921.1	hypothetical protein	-
RORB6_RS06370	1418452..1419084	-	633	WP_015584339.1	class I SAM-dependent methyltransferase	-
RORB6_RS06375	1419104..1420345	-	1242	WP_015584340.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 49327.66 Da
• Isoelectric Point: 6.7012

>T29358 WP_015584335.1 NC_021066:c1415690-1414359 [Raoultella ornithinolytica B6]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Nucleotide

• Length: 1332 bp

>T29358 NC_021066:c1415690-1414359 [Raoultella ornithinolytica B6]
ATGGCGACTCTCGTGACATGGATGAACAATGAGCGGGTCGGCGAGCTAATCAAGCAGGCGAACGGCGCACATCTCTTTCG
CTATGAAGAGGCGTGGATGCGCAATCCGCGCGCCAGACCGCTCTCACTGTCGCTTCCGCTGCAGTACGGTAACATCACCG
ACGAGGCGGTATTTAACTACTTTGACAATCTGCTGCCGGACAGTCCGCGGGTACGGGACCGCATTGTTAAGCGCTATCAG
GCGCGTTCAAAGCAGCCGTTTGATCTGCTGGCCGAGATCGGACGGGACAGCGTCGGGGCGGTAACGTTACTCCCGCCAGG
AGAAAATGCGCCCCGCGGGGCGTTGAGCTGGGAGCCGCTGGATAACCACGCTCTGGATGCGTTACTGACGGCCTACCAGT
CGGATATACCGCTCGGAATGGTCAACGAACACGATGATTTCAGGATCTCGGTGGCCGGGGCCCAGGAGAAAACCGCGCTG
CTGAAAATCGGCGAGCAGTGGTGTATCCCGACGGGTACCACGCCGACTACCCACATCATTAAACTGCCCATCGGCGAGAT
CAAACAGCCGGATGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATTTGTGTCTGGCGCTGGCCCGGGCGCTGG
GTTTTGCCGTTCCACCCGCCAGCATTATCCAGACAGCCAGTATCAGGGCGCTGGCGGTGGAGCGTTTCGACCGTCGCTGG
GCGCAGGAGAAAACGGTGCTGCTGCGTTTGCCGCAGGAAGATCTGTGTCAGGCCTTCGGCATTCCGTCATCGATTAAGTA
TGAGTCCGACGGCGGGCCGGGCATTCGGGCAATTATGGCTTTTCTGGTTGGCTCCAGCGAGGCACTCGAGGATCGCTATA
ACTTTATGAAGTTTATGGTGTTCCAGTGGCTGATTGGCGCAACCGATGGCCACGCCAAAAACTTCTCGATATTCCTCCAG
CCGGGCGGCAGCTACCGCTTAACCCCGTTCTACGACATTATCTCCGCGTTTCCGCTGCTTGGCGGAAAGGGACTGCACCT
GAGCGATCTCAAGCTGTCGATGAGTCTGAAGGCCAGTAAAGGGCGTAAAACGGAGATCCAGACGCTCTATCCGCGTCACT
TTCTCGCCACGGCTAAAGAGGTAGGGTTTGCCCAACAGCAGATGCTGGAGATTCTGCGCTATTTTGTCGATAACGTTCCC
CGCGCGGTTGAGGCGGTAAAGGGGACTTTACCGCCTGACTTTTCACAACCGGTATATGAGGCGATCACCGATCGCTTACT
GTGGGTCCATTCACGCTTGCAGAACGCAATGGCGGCGTCTCCGTCGGGCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10369.70 Da
• Isoelectric Point: 5.7971

>AT29358 WP_015584336.1 NC_021066:c1415962-1415690 [Raoultella ornithinolytica B6]
MSTSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Nucleotide

• Length: 273 bp

>AT29358 NC_021066:c1415962-1415690 [Raoultella ornithinolytica B6]
ATGAGCACTTCACCAACGATATACAGCCCGGTTCAGCTGGCAAACTATCTCAAGCTGGTGCGCCAGAAAAACCAGTGGAC
GCAGAGCGAGCTGGCTCAGCGTATGGGGATTAAACAGGCCACCGTCTCTAACTTTGAAAATCATCCCGAGAAAACGACGT
TAACCACGGTGTTTAAAATTTTACAGTCACTGGAACTGTCGATGGCGATTTGCGAAAAAAATGCGCCGGATACCGACGAT
AACCGTGATAACCCGCGGGATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A1Y6GHD8