Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 20095..20620 Replicon plasmid 2
Accession NZ_LT855377
Organism Salmonella enterica subsp. enterica serovar Typhimurium isolate STMU2UK

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag STMU2UK_RS24645 Protein ID WP_001159863.1
Coordinates 20315..20620 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag STMU2UK_RS24640 Protein ID WP_000813641.1
Coordinates 20095..20313 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STMU2UK_RS24605 15382..15763 + 382 Protein_20 YgiW/YdeI family stress tolerance OB fold protein -
STMU2UK_RS25285 15932..16376 + 445 Protein_21 site-specific integrase -
STMU2UK_RS24620 16635..17624 - 990 WP_001527061.1 RepB family plasmid replication initiator protein -
STMU2UK_RS24625 18118..18414 - 297 WP_001687482.1 hypothetical protein -
STMU2UK_RS24635 18898..19419 - 522 WP_010999942.1 hypothetical protein -
STMU2UK_RS24640 20095..20313 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
STMU2UK_RS24645 20315..20620 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
STMU2UK_RS24650 20622..20912 + 291 WP_001266176.1 hypothetical protein -
STMU2UK_RS24655 20909..21430 + 522 WP_000198608.1 hypothetical protein -
STMU2UK_RS24660 21465..22247 + 783 WP_000082169.1 site-specific integrase -
STMU2UK_RS24665 22256..22969 + 714 Protein_30 EAL domain-containing protein -
STMU2UK_RS24675 22973..23482 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
STMU2UK_RS24680 23476..23961 + 486 WP_000905606.1 membrane protein -
STMU2UK_RS25290 24238..24525 - 288 WP_071530243.1 hypothetical protein -
STMU2UK_RS24685 24681..25241 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93862 93862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T293575 WP_001159863.1 NZ_LT855377:20315-20620 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT293575 WP_000813641.1 NZ_LT855377:20095-20313 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References