Detailed information of TA system TA293574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/YoeB-RelB
• Location: 1376589..1377114
• Replicon: chromosome
• Accession: NZ_LT854705
• Organism: Levilactobacillus zymae strain ACA-DC 3411

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: -
• Locus tag: LZ3411_RS06440
• Protein ID: WP_087742015.1
• Coordinates: 1376857..1377114 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: LZ3411_RS06435
• Protein ID: WP_087742014.1
• Coordinates: 1376589..1376855 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ3411_RS06405	1371713..1372567	-	855	WP_087742008.1	aldo/keto reductase	-
LZ3411_RS06410	1372585..1373187	-	603	WP_087742009.1	NAD(P)H-binding protein	-
LZ3411_RS06415	1373189..1373632	-	444	WP_087742010.1	nuclear transport factor 2 family protein	-
LZ3411_RS06420	1373753..1375207	-	1455	WP_087742011.1	MFS transporter	-
LZ3411_RS06425	1375221..1375598	-	378	WP_087742012.1	nuclear transport factor 2 family protein	-
LZ3411_RS06430	1375779..1376363	-	585	WP_087742013.1	TetR/AcrR family transcriptional regulator	-
LZ3411_RS06435	1376589..1376855	+	267	WP_087742014.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LZ3411_RS06440	1376857..1377114	+	258	WP_087742015.1	Txe/YoeB family addiction module toxin	Toxin
LZ3411_RS06445	1377227..1378054	-	828	WP_087742016.1	NmrA family NAD(P)-binding protein	-
LZ3411_RS06450	1378186..1378743	+	558	WP_087742017.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
LZ3411_RS06455	1378815..1379345	-	531	WP_087742018.1	serine hydrolase	-
LZ3411_RS06460	1379345..1380226	-	882	WP_087742019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10391.72 Da
• Isoelectric Point: 9.4545

>T293574 WP_087742015.1 NZ_LT854705:1376857-1377114 [Levilactobacillus zymae]
MGIYWSDDAWQDYRYWQDQGDKKKLRKINALIKDITRHPFSGQGKPEPLKHELTGKWSRRITGEYRLIYRIEDDALYLYS
ARDYY

Nucleotide

• Length: 258 bp

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10023.24 Da
• Isoelectric Point: 4.4906

>AT293574 WP_087742014.1 NZ_LT854705:1376589-1376855 [Levilactobacillus zymae]
MDAVNYTNFRQNLKSFMKTVNEDSEPLIVTTKKGEDDVVVLSKDDYDAMTETMRILSNQPLMDKIRRGDAQFAKGQGKQH
ALIDPEDD

Nucleotide

• Length: 267 bp