Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 23312..23862 Replicon plasmid pPD885-27
Accession NZ_LT853884
Organism Xanthomonas fragariae strain PD885

Toxin (Protein)


Gene name parE Uniprot ID A0A1Y6HCU7
Locus tag PD885_RS20195 Protein ID WP_002804295.1
Coordinates 23312..23596 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1Y6HDJ6
Locus tag PD885_RS20200 Protein ID WP_002804296.1
Coordinates 23584..23862 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PD885_RS20170 18918..19319 - 402 WP_002804331.1 hypothetical protein -
PD885_RS21220 19371..19814 + 444 WP_145954081.1 hypothetical protein -
PD885_RS21665 19821..19985 + 165 WP_156775378.1 hypothetical protein -
PD885_RS20175 20173..20748 + 576 WP_040762337.1 recombinase family protein -
PD885_RS20180 20759..21025 + 267 WP_002804333.1 hypothetical protein -
PD885_RS20185 21160..22875 + 1716 WP_083215115.1 AAA family ATPase -
PD885_RS20190 22944..23126 + 183 WP_134656646.1 hypothetical protein -
PD885_RS20195 23312..23596 - 285 WP_002804295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PD885_RS20200 23584..23862 - 279 WP_002804296.1 CopG family ribbon-helix-helix protein Antitoxin
PD885_RS20210 24409..24834 + 426 WP_172404533.1 antitoxin VbhA family protein -
PD885_RS20215 24876..25427 + 552 WP_088057164.1 recombinase family protein -
PD885_RS20220 25530..26162 + 633 WP_088057159.1 ParA family protein -
PD885_RS20225 26155..26517 + 363 WP_088057160.1 hypothetical protein -
PD885_RS20230 26600..26923 + 324 WP_088057161.1 partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..27106 27106
- inside IScluster/Tn - - 20134..25427 5293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10801.49 Da        Isoelectric Point: 10.0858

>T293568 WP_002804295.1 NZ_LT853884:c23596-23312 [Xanthomonas fragariae]
VPHLIWTPPALADVQRLYRFLAPKDADAARRAVQAIRAQVKILAHQPRIGRPVEDMAPEFRDWLIDFGDSGYVARYRINE
NMVTILAVRHQKEA

Download         Length: 285 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10760.05 Da        Isoelectric Point: 5.1991

>AT293568 WP_002804296.1 NZ_LT853884:c23862-23584 [Xanthomonas fragariae]
MASPTSLKLDDELKGRVQHLAQTQRRTPHWIMREAIAQYVEREEKRETFKQDALRAWEDYQRTGLHLTLEETDAWLAKLE
AGEDAELPACHT

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6HCU7

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y6HDJ6

References