Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2069121..2069791 Replicon chromosome
Accession NZ_LT853882
Organism Xanthomonas fragariae strain PD885

Toxin (Protein)


Gene name vapC Uniprot ID A0A1Y6H9H7
Locus tag PD885_RS09660 Protein ID WP_002805728.1
Coordinates 2069372..2069791 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1Y6HLT7
Locus tag PD885_RS09655 Protein ID WP_002805732.1
Coordinates 2069121..2069375 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PD885_RS09630 2064706..2065710 - 1005 WP_002805744.1 hypothetical protein -
PD885_RS09635 2065792..2066025 + 234 WP_002805742.1 hypothetical protein -
PD885_RS09640 2066029..2066907 + 879 WP_002805739.1 helicase RepA family protein -
PD885_RS09645 2066879..2067766 + 888 WP_172404498.1 replication protein C -
PD885_RS09650 2068428..2068709 + 282 WP_002805735.1 TraK family protein -
PD885_RS09655 2069121..2069375 + 255 WP_002805732.1 Arc family DNA-binding protein Antitoxin
PD885_RS09660 2069372..2069791 + 420 WP_002805728.1 type II toxin-antitoxin system VapC family toxin Toxin
PD885_RS09665 2069948..2070562 + 615 WP_040762517.1 P-type conjugative transfer protein TrbJ -
PD885_RS09670 2070648..2070890 + 243 Protein_1836 transposase -
PD885_RS09675 2071008..2072375 + 1368 WP_088056828.1 IS5 family transposase -
PD885_RS09680 2072398..2073303 + 906 Protein_1838 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2036406..2072279 35873
- flank IS/Tn - - 2063295..2064632 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14879.07 Da        Isoelectric Point: 5.1890

>T293563 WP_002805728.1 NZ_LT853882:2069372-2069791 [Xanthomonas fragariae]
MIVLDTNVVSEAIKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9522.89 Da        Isoelectric Point: 5.7425

>AT293563 WP_002805732.1 NZ_LT853882:2069121-2069375 [Xanthomonas fragariae]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRQVVLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6H9H7

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y6HLT7

References