Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1772..2319 Replicon plasmid pWI2-incFII
Accession NZ_LT838203
Organism Escherichia coli isolate WI2 isolate

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag DSZ51_RS25450 Protein ID WP_000969996.1
Coordinates 2038..2319 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1X3K043
Locus tag DSZ51_RS25445 Protein ID WP_061360246.1
Coordinates 1772..2041 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSZ51_RS26925 1..858 + 858 WP_000131006.1 incFII family plasmid replication initiator RepA -
DSZ51_RS25445 1772..2041 + 270 WP_061360246.1 hypothetical protein Antitoxin
DSZ51_RS25450 2038..2319 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSZ51_RS25455 2583..3770 + 1188 WP_085543286.1 hypothetical protein -
DSZ51_RS25460 3859..4779 + 921 WP_085543287.1 toll/interleukin-1 receptor domain-containing protein -
DSZ51_RS25465 4921..5316 - 396 WP_000445930.1 plasmid partitioning/stability family protein -
DSZ51_RS25470 5316..6275 - 960 WP_000921958.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..60622 60622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T293554 WP_000969996.1 NZ_LT838203:2038-2319 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10284.64 Da        Isoelectric Point: 7.2057

>AT293554 WP_061360246.1 NZ_LT838203:1772-2041 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDMLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A1X3K043

References