Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2295485..2296011 Replicon chromosome
Accession NZ_LT838200
Organism Escherichia coli isolate WI2 isolate

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DSZ51_RS11825 Protein ID WP_000323025.1
Coordinates 2295724..2296011 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DSZ51_RS11820 Protein ID WP_000534858.1
Coordinates 2295485..2295724 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSZ51_RS11780 2290844..2291191 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
DSZ51_RS11785 2291188..2291592 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
DSZ51_RS26890 2291814..2292101 + 288 Protein_2171 hypothetical protein -
DSZ51_RS11800 2292870..2294183 + 1314 WP_000589005.1 ISNCY family transposase -
DSZ51_RS11810 2294620..2294952 - 333 WP_001301033.1 protein FlxA -
DSZ51_RS11815 2295155..2295460 - 306 WP_001326990.1 hypothetical protein -
DSZ51_RS11820 2295485..2295724 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DSZ51_RS11825 2295724..2296011 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DSZ51_RS11830 2296083..2296238 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
DSZ51_RS11835 2296455..2296706 + 252 WP_000980994.1 hypothetical protein -
DSZ51_RS11840 2296773..2297051 + 279 WP_012304870.1 hypothetical protein -
DSZ51_RS11845 2297053..2298102 + 1050 WP_001265199.1 DUF968 domain-containing protein -
DSZ51_RS11850 2298116..2298868 + 753 WP_001047135.1 antitermination protein -
DSZ51_RS26535 2299146..2299235 - 90 WP_120795389.1 hypothetical protein -
DSZ51_RS11855 2299290..2299502 - 213 WP_000087756.1 cold shock-like protein CspF -
DSZ51_RS11860 2299803..2300018 + 216 WP_000066484.1 cold shock-like protein CspB -
DSZ51_RS27015 2300382..2300552 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
DSZ51_RS11865 2300772..2300987 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2268150..2338367 70217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293544 WP_000323025.1 NZ_LT838200:2295724-2296011 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT293544 WP_000534858.1 NZ_LT838200:2295485-2295724 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References