Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3539523..3540141 Replicon chromosome
Accession NZ_LT838196
Organism Escherichia coli isolate WI1 isolate

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag WI2_RS18315 Protein ID WP_001291435.1
Coordinates 3539923..3540141 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag WI2_RS18310 Protein ID WP_000344800.1
Coordinates 3539523..3539897 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI2_RS18300 3534612..3535805 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
WI2_RS18305 3535828..3538977 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
WI2_RS18310 3539523..3539897 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
WI2_RS18315 3539923..3540141 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
WI2_RS18320 3540313..3540864 + 552 WP_000102564.1 maltose O-acetyltransferase -
WI2_RS18325 3540980..3541450 + 471 WP_000136192.1 YlaC family protein -
WI2_RS18330 3541614..3543164 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
WI2_RS18335 3543206..3543559 - 354 WP_000878140.1 DUF1428 domain-containing protein -
WI2_RS18345 3543938..3544249 + 312 WP_000409911.1 MGMT family protein -
WI2_RS18350 3544280..3544852 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T293522 WP_001291435.1 NZ_LT838196:3539923-3540141 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT293522 WP_000344800.1 NZ_LT838196:3539523-3539897 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References