Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2469639..2470277 Replicon chromosome
Accession NZ_LT838196
Organism Escherichia coli isolate WI1 isolate

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag WI2_RS12700 Protein ID WP_001447010.1
Coordinates 2470101..2470277 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag WI2_RS12695 Protein ID WP_001270286.1
Coordinates 2469639..2470055 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI2_RS12675 2464791..2465732 - 942 WP_001251304.1 ABC transporter permease -
WI2_RS12680 2465733..2466746 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
WI2_RS12685 2466764..2467909 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
WI2_RS12690 2468154..2469560 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
WI2_RS12695 2469639..2470055 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
WI2_RS12700 2470101..2470277 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
WI2_RS12705 2470499..2470729 + 231 WP_000494244.1 YncJ family protein -
WI2_RS12710 2470821..2472782 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
WI2_RS12715 2472855..2473391 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
WI2_RS12720 2473444..2474658 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T293521 WP_001447010.1 NZ_LT838196:c2470277-2470101 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT293521 WP_001270286.1 NZ_LT838196:c2470055-2469639 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References