Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2295477..2296003 Replicon chromosome
Accession NZ_LT838196
Organism Escherichia coli isolate WI1 isolate

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag WI2_RS11785 Protein ID WP_000323025.1
Coordinates 2295716..2296003 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag WI2_RS11780 Protein ID WP_000534858.1
Coordinates 2295477..2295716 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI2_RS11740 2290836..2291183 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
WI2_RS11745 2291180..2291584 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
WI2_RS26855 2291806..2292093 + 288 Protein_2171 hypothetical protein -
WI2_RS11765 2292862..2294175 + 1314 WP_000589005.1 ISNCY family transposase -
WI2_RS11770 2294612..2294944 - 333 WP_001301033.1 protein FlxA -
WI2_RS11775 2295147..2295452 - 306 WP_001326990.1 hypothetical protein -
WI2_RS11780 2295477..2295716 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
WI2_RS11785 2295716..2296003 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
WI2_RS11790 2296075..2296230 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
WI2_RS11795 2296447..2296698 + 252 WP_000980994.1 hypothetical protein -
WI2_RS11800 2296765..2297043 + 279 WP_012304870.1 hypothetical protein -
WI2_RS11805 2297045..2298094 + 1050 WP_001265199.1 DUF968 domain-containing protein -
WI2_RS11810 2298108..2298860 + 753 WP_001047135.1 antitermination protein -
WI2_RS26265 2299138..2299227 - 90 WP_120795389.1 hypothetical protein -
WI2_RS11815 2299282..2299494 - 213 WP_000087756.1 cold shock-like protein CspF -
WI2_RS11820 2299795..2300010 + 216 WP_000066484.1 cold shock-like protein CspB -
WI2_RS26995 2300374..2300544 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
WI2_RS11825 2300764..2300979 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2268142..2328598 60456
- inside Prophage - - 2263013..2344795 81782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293519 WP_000323025.1 NZ_LT838196:2295716-2296003 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT293519 WP_000534858.1 NZ_LT838196:2295477-2295716 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References