Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3205764..3206418 Replicon chromosome
Accession NZ_LT827011
Organism Escherichia coli O127:H6 isolate EPEC E2348/69 variety

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag BQ9544_RS17175 Protein ID WP_000244781.1
Coordinates 3205764..3206171 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag BQ9544_RS17180 Protein ID WP_000354046.1
Coordinates 3206152..3206418 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9544_RS17155 3201721..3203454 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
BQ9544_RS17160 3203460..3204170 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BQ9544_RS17165 3204195..3205091 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
BQ9544_RS17170 3205203..3205724 + 522 WP_001055874.1 flavodoxin FldB -
BQ9544_RS17175 3205764..3206171 - 408 WP_000244781.1 protein YgfX Toxin
BQ9544_RS17180 3206152..3206418 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
BQ9544_RS17185 3206661..3207641 + 981 WP_000886076.1 tRNA-modifying protein YgfZ -
BQ9544_RS17190 3207718..3208377 - 660 WP_000250274.1 hemolysin III family protein -
BQ9544_RS17195 3208541..3208852 - 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
BQ9544_RS17200 3208897..3210330 + 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T293503 WP_000244781.1 NZ_LT827011:c3206171-3205764 [Escherichia coli O127:H6]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT293503 WP_000354046.1 NZ_LT827011:c3206418-3206152 [Escherichia coli O127:H6]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References