Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1661895..1663483 Replicon chromosome
Accession NZ_LT827011
Organism Escherichia coli O127:H6 isolate EPEC E2348/69 variety

Toxin (Protein)


Gene name hipA Uniprot ID B7URP4
Locus tag BQ9544_RS08940 Protein ID WP_001125430.1
Coordinates 1661895..1663217 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BQ9544_RS08945 Protein ID WP_001334382.1
Coordinates 1663217..1663483 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9544_RS08910 1657562..1658047 + 486 WP_001015823.1 hypothetical protein -
BQ9544_RS08915 1658050..1659876 + 1827 WP_012578907.1 AAA family ATPase -
BQ9544_RS08920 1660203..1660505 + 303 WP_000343124.1 hypothetical protein -
BQ9544_RS08925 1660873..1661256 + 384 Protein_1634 RNA-directed DNA polymerase -
BQ9544_RS08935 1661398..1661649 - 252 WP_029694049.1 hypothetical protein -
BQ9544_RS26000 1661641..1661787 - 147 Protein_1636 site-specific integrase -
BQ9544_RS08940 1661895..1663217 - 1323 WP_001125430.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
BQ9544_RS08945 1663217..1663483 - 267 WP_001334382.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
BQ9544_RS08950 1663790..1664548 + 759 WP_001286539.1 trans-aconitate 2-methyltransferase -
BQ9544_RS08955 1664552..1665466 - 915 WP_001313828.1 bestrophin family inner membrane protein -
BQ9544_RS08965 1665663..1667114 - 1452 WP_000854637.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49297.96 Da        Isoelectric Point: 8.1297

>T293495 WP_001125430.1 NZ_LT827011:c1663217-1661895 [Escherichia coli O127:H6]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10017.42 Da        Isoelectric Point: 4.9632

>AT293495 WP_001334382.1 NZ_LT827011:c1663483-1663217 [Escherichia coli O127:H6]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4M2E2

Antitoxin

Source ID Structure

References