Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1528775..1529289 Replicon chromosome
Accession NZ_LT827010
Organism Actinoplanes sp. SE50/110 isolate ACP50

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ACSP50_RS06905 Protein ID WP_014688436.1
Coordinates 1528775..1529035 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G8S4Y5
Locus tag ACSP50_RS06910 Protein ID WP_014688437.1
Coordinates 1529032..1529289 (-) Length 86 a.a.

Genomic Context

ACSP50_RS06890ACSP50_RS06895ACSP50_RS06900ACSP50_RS06930ACSP50_RS06940ACSP50_RS06905ACSP50_RS06910ACSP50_RS06920ACSP50_RS41615ACSP50_RS06935
Location: 1524302..1526392 (2091 bp)
Type: Others
Protein ID: WP_080127737.1
Location: 1526830..1527957 (1128 bp)
Type: Others
Protein ID: WP_197688122.1
Location: 1528015..1528752 (738 bp)
Type: Others
Protein ID: WP_014688435.1
Location: 1531669..1531920 (252 bp)
Type: Others
Protein ID: WP_155123448.1
Location: 1532789..1533151 (363 bp)
Type: Others
Protein ID: WP_014688443.1
Location: 1528775..1529035 (261 bp)
Type: Toxin
Protein ID: WP_014688436.1
Location: 1529032..1529289 (258 bp)
Type: Antitoxin
Protein ID: WP_014688437.1
Location: 1530748..1531149 (402 bp)
Type: Others
Protein ID: WP_043510958.1
Location: 1531259..1531480 (222 bp)
Type: Others
Protein ID: WP_155123447.1
Location: 1532020..1532730 (711 bp)
Type: Others
Protein ID: WP_014688442.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ACSP50_RS068901524302..1526392+2091WP_080127737.1UvrD-helicase domain-containing protein-
ACSP50_RS068951526830..1527957+1128WP_197688122.1hypothetical protein-
ACSP50_RS069001528015..1528752+738WP_014688435.1hypothetical protein-
ACSP50_RS069051528775..1529035-261WP_014688436.1Txe/YoeB family addiction module toxinToxin
ACSP50_RS069101529032..1529289-258WP_014688437.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
ACSP50_RS069201530748..1531149-402WP_043510958.1hypothetical protein-
ACSP50_RS416151531259..1531480-222WP_155123447.1hypothetical protein-
ACSP50_RS069301531669..1531920+252WP_155123448.1hypothetical protein-
ACSP50_RS069351532020..1532730-711WP_014688442.1SDR family oxidoreductase-
ACSP50_RS069401532789..1533151+363WP_014688443.1MerR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10231.53 Da        Isoelectric Point: 8.0720

>T293488 WP_014688436.1 NZ_LT827010:c1529035-1528775 [Actinoplanes sp. SE50/110]
VKLSWTDHAWDDYLYRQTQDRRTLKRINALIADIKRDPDGQGIGKPEILRNNLAGLRSRRIDDEHRMVYAVETNEITIIS
CRYHHE

Download         Length: 261 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9598.77 Da        Isoelectric Point: 5.1667

>AT293488 WP_014688437.1 NZ_LT827010:c1529289-1529032 [Actinoplanes sp. SE50/110]
VTSAISASEARKSLFPLIERVNLDHTPIEIVSKRGNAVLVSKEDWDSIMETNYLLRSPANAKRLTESVEQWRAGRATERE
FGPEE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBG8S4Y5

References