Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1528775..1529289 Replicon chromosome
Accession NZ_LT827010
Organism Actinoplanes sp. SE50/110 isolate ACP50

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ACSP50_RS06905 Protein ID WP_014688436.1
Coordinates 1528775..1529035 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G8S4Y5
Locus tag ACSP50_RS06910 Protein ID WP_014688437.1
Coordinates 1529032..1529289 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACSP50_RS06890 1524302..1526392 + 2091 WP_080127737.1 UvrD-helicase domain-containing protein -
ACSP50_RS06895 1526830..1527957 + 1128 WP_197688122.1 hypothetical protein -
ACSP50_RS06900 1528015..1528752 + 738 WP_014688435.1 hypothetical protein -
ACSP50_RS06905 1528775..1529035 - 261 WP_014688436.1 Txe/YoeB family addiction module toxin Toxin
ACSP50_RS06910 1529032..1529289 - 258 WP_014688437.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ACSP50_RS06920 1530748..1531149 - 402 WP_043510958.1 hypothetical protein -
ACSP50_RS41615 1531259..1531480 - 222 WP_155123447.1 hypothetical protein -
ACSP50_RS06930 1531669..1531920 + 252 WP_155123448.1 hypothetical protein -
ACSP50_RS06935 1532020..1532730 - 711 WP_014688442.1 SDR family oxidoreductase -
ACSP50_RS06940 1532789..1533151 + 363 WP_014688443.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10231.53 Da        Isoelectric Point: 8.0720

>T293488 WP_014688436.1 NZ_LT827010:c1529035-1528775 [Actinoplanes sp. SE50/110]
VKLSWTDHAWDDYLYRQTQDRRTLKRINALIADIKRDPDGQGIGKPEILRNNLAGLRSRRIDDEHRMVYAVETNEITIIS
CRYHHE

Download         Length: 261 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9598.77 Da        Isoelectric Point: 5.1667

>AT293488 WP_014688437.1 NZ_LT827010:c1529289-1529032 [Actinoplanes sp. SE50/110]
VTSAISASEARKSLFPLIERVNLDHTPIEIVSKRGNAVLVSKEDWDSIMETNYLLRSPANAKRLTESVEQWRAGRATERE
FGPEE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G8S4Y5

References