Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4502104..4502601 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KJB12_RS21410 Protein ID WP_001173343.1
Coordinates 4502104..4502277 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag KJB12_RS21415 Protein ID WP_000398619.1
Coordinates 4502305..4502601 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS21400 (4498774) 4498774..4500231 + 1458 WP_000856836.1 dipeptide/tripeptide permease DtpC -
KJB12_RS21405 (4500468) 4500468..4501985 + 1518 WP_001295065.1 lysine--tRNA ligase -
KJB12_RS21410 (4502104) 4502104..4502277 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KJB12_RS21415 (4502305) 4502305..4502601 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KJB12_RS21420 (4502828) 4502828..4503100 - 273 WP_000405653.1 GNAT family N-acetyltransferase -
KJB12_RS21425 (4503112) 4503112..4503342 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
KJB12_RS21430 (4503523) 4503523..4505154 + 1632 WP_001216470.1 sensor histidine kinase -
KJB12_RS21435 (4505151) 4505151..4505870 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T293479 WP_001173343.1 NZ_LT795502:c4502277-4502104 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT293479 WP_000398619.1 NZ_LT795502:c4502601-4502305 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References