Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4301479..4302293 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KJB12_RS20390 Protein ID WP_001054376.1
Coordinates 4301479..4301736 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KJB12_RS20395 Protein ID WP_001309181.1
Coordinates 4301748..4302293 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS20370 (4296767) 4296767..4297873 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
KJB12_RS20375 (4297938) 4297938..4298918 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KJB12_RS26915 (4299028) 4299028..4299233 + 206 Protein_4010 HNH endonuclease -
KJB12_RS20380 (4299501) 4299501..4300741 - 1241 Protein_4011 helicase YjhR -
KJB12_RS26920 (4300857) 4300857..4300988 + 132 WP_001309182.1 hypothetical protein -
KJB12_RS20390 (4301479) 4301479..4301736 + 258 WP_001054376.1 YjhX family toxin Toxin
KJB12_RS20395 (4301748) 4301748..4302293 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
KJB12_RS20400 (4302349) 4302349..4303095 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KJB12_RS20405 (4303264) 4303264..4303482 + 219 Protein_4016 hypothetical protein -
KJB12_RS20410 (4303520) 4303520..4303636 + 117 Protein_4017 VOC family protein -
KJB12_RS20415 (4303881) 4303881..4305002 + 1122 WP_000010829.1 M42 family metallopeptidase -
KJB12_RS20420 (4304999) 4304999..4305277 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KJB12_RS20425 (4305289) 4305289..4306602 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4293973..4310517 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T293477 WP_001054376.1 NZ_LT795502:4301479-4301736 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT293477 WP_001309181.1 NZ_LT795502:4301748-4302293 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References