Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3665842..3666460 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KJB12_RS17510 Protein ID WP_001291435.1
Coordinates 3666242..3666460 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KJB12_RS17505 Protein ID WP_000344800.1
Coordinates 3665842..3666216 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS17495 (3660931) 3660931..3662124 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KJB12_RS17500 (3662147) 3662147..3665296 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KJB12_RS17505 (3665842) 3665842..3666216 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KJB12_RS17510 (3666242) 3666242..3666460 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KJB12_RS17515 (3666632) 3666632..3667183 + 552 WP_000102564.1 maltose O-acetyltransferase -
KJB12_RS17520 (3667299) 3667299..3667769 + 471 WP_000136192.1 YlaC family protein -
KJB12_RS17525 (3667933) 3667933..3669483 + 1551 WP_213222217.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KJB12_RS17530 (3669525) 3669525..3669878 - 354 WP_000878146.1 DUF1428 family protein -
KJB12_RS17540 (3670257) 3670257..3670568 + 312 WP_000409914.1 MGMT family protein -
KJB12_RS17545 (3670599) 3670599..3671171 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T293473 WP_001291435.1 NZ_LT795502:3666242-3666460 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT293473 WP_000344800.1 NZ_LT795502:3665842-3666216 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References