293472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2521154..2521792 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name hicA Uniprot ID A0A080J2T0
Locus tag KJB12_RS12150 Protein ID WP_000813793.1
Coordinates 2521616..2521792 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KJB12_RS12145 Protein ID WP_001270286.1
Coordinates 2521154..2521570 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS12125 (2516306) 2516306..2517247 - 942 WP_001251315.1 ABC transporter permease -
KJB12_RS12130 (2517248) 2517248..2518261 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
KJB12_RS12135 (2518279) 2518279..2519424 - 1146 WP_000047419.1 ABC transporter substrate-binding protein -
KJB12_RS12140 (2519669) 2519669..2521075 - 1407 WP_000760655.1 PLP-dependent aminotransferase family protein -
KJB12_RS12145 (2521154) 2521154..2521570 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KJB12_RS12150 (2521616) 2521616..2521792 - 177 WP_000813793.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KJB12_RS12155 (2522014) 2522014..2522244 + 231 WP_000494244.1 YncJ family protein -
KJB12_RS12160 (2522336) 2522336..2524297 - 1962 WP_024257894.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KJB12_RS12165 (2524370) 2524370..2524906 - 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
KJB12_RS12170 (2524959) 2524959..2526170 + 1212 WP_023154256.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.83 Da        Isoelectric Point: 10.9223

>T293472 WP_000813793.1 NZ_LT795502:c2521792-2521616 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGMRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT293472 WP_001270286.1 NZ_LT795502:c2521570-2521154 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A080J2T0

Antitoxin

Source ID Structure

References