Detailed information of TA system TA029347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1960287..1960893
• Replicon: chromosome
• Accession: NC_021058
• Organism: Sulfolobus islandicus LAL14/1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M9UBU6
• Locus tag: SIL_RS10745
• Protein ID: WP_014513042.1
• Coordinates: 1960489..1960893 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UBQ9
• Locus tag: SIL_RS10740
• Protein ID: WP_009989091.1
• Coordinates: 1960287..1960508 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIL_RS10710	1956110..1956727	+	618	WP_012712231.1	hypothetical protein	-
SIL_RS10715 (SiL_2130)	1956724..1957110	+	387	WP_048050269.1	hypothetical protein	-
SIL_RS10720 (SiL_2131)	1957107..1957772	-	666	WP_014513040.1	helix-turn-helix domain-containing protein	-
SIL_RS10725 (SiL_2132)	1957891..1959162	-	1272	WP_015581507.1	MFS transporter	-
SIL_RS10730 (SiL_2133)	1959217..1959528	-	312	WP_258164983.1	DMT family transporter	-
SIL_RS10735	1959563..1959757	-	195	WP_048050270.1	hypothetical protein	-
SIL_RS10740 (SiL_2134)	1960287..1960508	+	222	WP_009989091.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SIL_RS10745 (SiL_2135)	1960489..1960893	+	405	WP_014513042.1	PIN domain-containing protein	Toxin
SIL_RS13835 (SiL_2136)	1961089..1961980	-	892	Protein_2175	IS110 family transposase	-
SIL_RS10765 (SiL_2137)	1962413..1963192	-	780	WP_014513043.1	DMT family transporter	-
SIL_RS10770 (SiL_2138)	1964157..1965314	-	1158	WP_015581759.1	RNA-guided endonuclease TnpB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1961561..1961965	404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (4-48)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15441.05 Da
• Isoelectric Point: 5.2947

>T29347 WP_014513042.1 NC_021058:1960489-1960893 [Sulfolobus islandicus LAL14/1]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLKKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Nucleotide

• Length: 405 bp

>T29347 NC_021058:1960489-1960893 [Sulfolobus islandicus LAL14/1]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAAGAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTACTACAGT
CGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8267.50 Da
• Isoelectric Point: 9.6908

>AT29347 WP_009989091.1 NC_021058:1960287-1960508 [Sulfolobus islandicus LAL14/1]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Nucleotide

• Length: 222 bp

>AT29347 NC_021058:1960287-1960508 [Sulfolobus islandicus LAL14/1]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCGGCCTCAGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Structures

Toxin

• AlphaFold DB: M9UBU6

Antitoxin

• AlphaFold DB: M9UBQ9