Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1345154..1345779 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag KJB12_RS06410 Protein ID WP_000911329.1
Coordinates 1345381..1345779 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KJB12_RS06405 Protein ID WP_000450524.1
Coordinates 1345154..1345381 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS06380 (1340956) 1340956..1341426 - 471 WP_001068690.1 thioredoxin-dependent thiol peroxidase -
KJB12_RS06385 (1341426) 1341426..1341998 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KJB12_RS06390 (1342144) 1342144..1343022 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KJB12_RS06395 (1343039) 1343039..1344073 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KJB12_RS06400 (1344286) 1344286..1344999 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KJB12_RS06405 (1345154) 1345154..1345381 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KJB12_RS06410 (1345381) 1345381..1345779 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
KJB12_RS06415 (1345926) 1345926..1346789 + 864 WP_001267498.1 neutral zinc metallopeptidase -
KJB12_RS06420 (1346804) 1346804..1348819 + 2016 WP_000829353.1 tRNA cytosine(34) acetyltransferase TmcA -
KJB12_RS06425 (1348893) 1348893..1349591 + 699 WP_000679812.1 esterase -
KJB12_RS06430 (1349672) 1349672..1349872 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T293464 WP_000911329.1 NZ_LT795502:1345381-1345779 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT293464 WP_000450524.1 NZ_LT795502:1345154-1345381 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References