Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 902736..903390 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KJB12_RS04330 Protein ID WP_000244777.1
Coordinates 902983..903390 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KJB12_RS04325 Protein ID WP_000354046.1
Coordinates 902736..903002 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS04305 (898866) 898866..899177 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
KJB12_RS04310 (899341) 899341..900000 + 660 WP_000250270.1 hemolysin III family protein -
KJB12_RS04315 (900087) 900087..901435 + 1349 WP_100245061.1 IS3-like element IS1397 family transposase -
KJB12_RS04320 (901513) 901513..902493 - 981 WP_000886100.1 tRNA-modifying protein YgfZ -
KJB12_RS04325 (902736) 902736..903002 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KJB12_RS04330 (902983) 902983..903390 + 408 WP_000244777.1 protein YgfX Toxin
KJB12_RS04335 (903430) 903430..903951 - 522 WP_001055874.1 flavodoxin FldB -
KJB12_RS04340 (904063) 904063..904959 + 897 WP_000806630.1 site-specific tyrosine recombinase XerD -
KJB12_RS04345 (904984) 904984..905694 + 711 WP_000715218.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KJB12_RS04350 (905700) 905700..907433 + 1734 WP_000813236.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T293462 WP_000244777.1 NZ_LT795502:902983-903390 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT293462 WP_000354046.1 NZ_LT795502:902736-903002 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References