Detailed information of TA system TA029346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 646931..647910
• Replicon: chromosome
• Accession: NC_021058
• Organism: Sulfolobus islandicus LAL14/1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M9U7R2
• Locus tag: SIL_RS03360
• Protein ID: WP_014512230.1
• Coordinates: 646931..647545 (-)
• Length: 205 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9U539
• Locus tag: SIL_RS03365
• Protein ID: WP_014512229.1
• Coordinates: 647563..647910 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIL_RS03310 (SiL_0661)	642072..642896	-	825	WP_014512237.1	DMT family transporter	-
SIL_RS03315 (SiL_0662)	642916..643137	-	222	WP_015580910.1	hypothetical protein	-
SIL_RS03320	643206..643394	-	189	WP_048050184.1	hypothetical protein	-
SIL_RS03325 (SiL_0663)	643491..644090	-	600	WP_015580911.1	DUF2249 domain-containing protein	-
SIL_RS03330 (SiL_0664)	644338..644565	+	228	WP_014512234.1	hypothetical protein	-
SIL_RS03335 (SiL_0665)	644546..644869	-	324	WP_014512233.1	hypothetical protein	-
SIL_RS03340 (SiL_0666)	644873..645637	-	765	WP_014512232.1	plastocyanin/azurin family copper-binding protein	-
SIL_RS14640 (SiL_0667)	646293..646487	-	195	WP_014513669.1	hypothetical protein	-
SIL_RS03355 (SiL_0668)	646612..646887	+	276	WP_014512231.1	hypothetical protein	-
SIL_RS03360 (SiL_0669)	646931..647545	-	615	WP_014512230.1	helix-turn-helix domain-containing protein	Toxin
SIL_RS03365 (SiL_0670)	647563..647910	-	348	WP_014512229.1	DUF488 domain-containing protein	Antitoxin
SIL_RS03370 (SiL_0671)	647979..648209	-	231	WP_015580912.1	C2H2-type zinc finger protein	-
SIL_RS03375	648300..648413	+	114	Protein_701	phenylacetic acid degradation protein	-
SIL_RS03380 (SiL_0673)	648455..648886	-	432	WP_014513674.1	universal stress protein	-
SIL_RS03385 (SiL_0674)	649204..650142	-	939	WP_014512225.1	dipeptidase	-
SIL_RS03390 (SiL_0675)	650087..651283	-	1197	WP_014512224.1	MFS transporter	-
SIL_RS03395 (SiL_0676)	651320..652153	-	834	WP_014513675.1	KaiC domain-containing protein	-
SIL_RS03400 (SiL_0677)	652310..652639	+	330	Protein_706	undecaprenyl-diphosphate phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (145-197)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 205 a.a.
• Molecular weight: 23353.44 Da
• Isoelectric Point: 9.4585

>T29346 WP_014512230.1 NC_021058:c647545-646931 [Sulfolobus islandicus LAL14/1]
MLKSPFEVTILIEDHPCEVMGVISSTGLKATVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSIKVLKFNDSKVWVRTK
GCSVCKILYSSNVVVEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQRIKFTVLSTYEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEIMRRALRKVVKYYLDKVG

Nucleotide

• Length: 615 bp

>T29346 NC_021058:c647545-646931 [Sulfolobus islandicus LAL14/1]
ATGTTAAAATCACCGTTCGAAGTAACAATCTTGATTGAAGATCACCCTTGTGAGGTTATGGGAGTAATATCTAGTACTGG
GCTTAAAGCAACTGTTGACAACGTTAAACTCGGGGATAATACAACTGATCACATAGTCCTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAACTTAAGTCCCATAGTATCAAAGTCTTAAAGTTTAATGATAGCAAAGTATGGGTTAGAACTAAG
GGATGCTCAGTATGTAAGATTCTCTATTCTTCAAATGTTGTCGTAGAGAAAATAAAAGTAATAAAAGAGAGAACATTACT
CTATACGCTTTTGGTCCCTAATACGATAGCTTTTAAGGAGTTTCTAGCTAATCTTACTAGTCAAAGGATAAAGTTTACAG
TCCTAAGCACCTATGAAATAAGCAGTAACGACTTAACTGATAGACAAATGGAAATATTAAAACTTGCATACAAGATGGGT
TATTTTGATGATGATAGGAGAGTAACTTTAACTGAATTAGCAAAGCAATTGGGAATATCAACTCCGACTTTGGAGGAAAT
TATGAGGAGAGCGTTAAGGAAAGTCGTCAAGTATTATTTAGATAAAGTAGGGTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13678.98 Da
• Isoelectric Point: 9.8667

>AT29346 WP_014512229.1 NC_021058:c647910-647563 [Sulfolobus islandicus LAL14/1]
MIKIKRVYDPIEKDDGLRVLVDRLWPRGIGKNKVDLWLKDIAPSDELRKWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKE

Nucleotide

• Length: 348 bp

>AT29346 NC_021058:c647910-647563 [Sulfolobus islandicus LAL14/1]
ATGATTAAGATAAAGAGGGTTTACGATCCAATAGAGAAAGATGACGGACTAAGAGTCTTAGTGGATAGGTTATGGCCAAG
AGGAATTGGCAAAAATAAGGTGGATTTATGGCTTAAAGATATAGCACCCAGTGATGAGTTACGAAAATGGTACGGTCATG
ATGCCAGTAAATGGGATGAGTTCAAAAGGAAATATTTTGAGGAACTAGATGCTAATCCAAAGATGAGTATTTTATTACAA
TTAATTAGAAAGGGCGAAAATATTACCTTACTTTACGCCTCCAAATCACCGTATAATAATGCAATTGCGTTAAAGGAGTA
TCTAGAGAAAAAGATATTAAAAGAATAG

Structures

Toxin

• AlphaFold DB: M9U7R2

Antitoxin

• AlphaFold DB: M9U539