Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 327359..328159 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name ataT Uniprot ID U9Y257
Locus tag KJB12_RS01505 Protein ID WP_000342447.1
Coordinates 327632..328159 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID U9Y285
Locus tag KJB12_RS01500 Protein ID WP_001277109.1
Coordinates 327359..327625 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS01480 (323017) 323017..323685 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
KJB12_RS01485 (323678) 323678..324736 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
KJB12_RS01490 (324981) 324981..325835 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
KJB12_RS01495 (326106) 326106..327209 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
KJB12_RS01500 (327359) 327359..327625 + 267 WP_001277109.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
KJB12_RS01505 (327632) 327632..328159 + 528 WP_000342447.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
KJB12_RS01510 (328156) 328156..328539 - 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
KJB12_RS01515 (328963) 328963..330072 + 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
KJB12_RS01520 (330120) 330120..331046 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KJB12_RS01525 (331043) 331043..332320 + 1278 WP_000803778.1 branched chain amino acid ABC transporter permease LivM -
KJB12_RS01530 (332317) 332317..333084 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.63 Da        Isoelectric Point: 7.0284

>T293459 WP_000342447.1 NZ_LT795502:327632-328159 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDHSIQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.37 Da        Isoelectric Point: 10.0863

>AT293459 WP_001277109.1 NZ_LT795502:327359-327625 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AVKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LUM2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LUN0

References