293458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 284928..285559 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag KJB12_RS01255 Protein ID WP_001259385.1
Coordinates 284928..285203 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KJB12_RS01260 Protein ID WP_000593555.1
Coordinates 285200..285559 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS01240 (279932) 279932..280999 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
KJB12_RS01245 (280996) 280996..283731 + 2736 WP_000149185.1 ribosome-associated ATPase/putative transporter RbbA -
KJB12_RS01250 (283731) 283731..284855 + 1125 WP_001314210.1 ABC transporter permease -
KJB12_RS01255 (284928) 284928..285203 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
KJB12_RS01260 (285200) 285200..285559 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KJB12_RS01265 (285609) 285609..286469 - 861 WP_001131795.1 class II aldolase -
KJB12_RS01270 (286501) 286501..286770 - 270 WP_000933060.1 HPr family phosphocarrier protein -
KJB12_RS01275 (286760) 286760..288268 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
KJB12_RS01280 (288261) 288261..289619 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
KJB12_RS01285 (289696) 289696..289977 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
KJB12_RS01290 (289974) 289974..290447 - 474 WP_001161550.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T293458 WP_001259385.1 NZ_LT795502:284928-285203 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT293458 WP_000593555.1 NZ_LT795502:285200-285559 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References