Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 115825..117448 Replicon plasmid p1
Accession NZ_LT795115
Organism Salmonella enterica subsp. enterica serovar Typhimurium isolate VNB151-sc-2315230

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag CS949_RS26465 Protein ID WP_000088046.1
Coordinates 115825..117150 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag CS949_RS26470 Protein ID WP_024136327.1
Coordinates 117155..117448 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS949_RS27330 112495..112794 - 300 WP_001572440.1 hypothetical protein -
CS949_RS26440 112849..113085 - 237 Protein_125 hypothetical protein -
CS949_RS26445 113539..113964 - 426 WP_001043843.1 hypothetical protein -
CS949_RS26450 114218..115033 - 816 WP_001572439.1 HNH endonuclease -
CS949_RS26455 115046..115456 - 411 WP_000985911.1 hypothetical protein -
CS949_RS26460 115558..115764 - 207 WP_000134171.1 hypothetical protein -
CS949_RS26465 115825..117150 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
CS949_RS26470 117155..117448 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
CS949_RS26480 118052..118444 - 393 WP_000341066.1 hypothetical protein -
CS949_RS26485 118817..119158 + 342 WP_001151575.1 hypothetical protein -
CS949_RS26490 119250..119441 + 192 WP_000398480.1 hypothetical protein -
CS949_RS26495 119491..119772 + 282 WP_000077926.1 hypothetical protein -
CS949_RS26500 120335..121576 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid oqxB / oqxA / sul1 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE - 1..246444 246444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T293457 WP_000088046.1 NZ_LT795115:c117150-115825 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT293457 WP_024136327.1 NZ_LT795115:c117448-117155 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References