Detailed information of TA system TA293456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/-
• Location: 1515297..1515963
• Replicon: chromosome
• Accession: NZ_LT717701
• Organism: Mycobacterium terramassiliense strain AB308

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MTAB308_RS21965
• Protein ID: WP_077102130.1
• Coordinates: 1515490..1515963 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: -
• Locus tag: MTAB308_RS21960
• Protein ID: WP_077102128.1
• Coordinates: 1515297..1515485 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTAB308_RS21950 (B0289_RS21880)	1511280..1512872	+	1593	WP_077102124.1	serine hydrolase	-
MTAB308_RS21955 (B0289_RS21885)	1512869..1515262	+	2394	WP_077102126.1	cation-translocating P-type ATPase	-
MTAB308_RS21960 (B0289_RS21890)	1515297..1515485	+	189	WP_077102128.1	antitoxin	Antitoxin
MTAB308_RS21965 (B0289_RS21895)	1515490..1515963	+	474	WP_077102130.1	SRPBCC family protein	Toxin
MTAB308_RS21970 (B0289_RS21900)	1516058..1516831	+	774	WP_077102132.1	VOC family protein	-
MTAB308_RS21975 (B0289_RS21905)	1516884..1517318	+	435	WP_077102134.1	hypothetical protein	-
MTAB308_RS21980 (B0289_RS21910)	1517323..1517805	-	483	WP_077102136.1	VOC family protein	-
MTAB308_RS21985 (B0289_RS21915)	1517808..1519322	-	1515	WP_077102138.1	carotenoid oxygenase family protein	-
MTAB308_RS21990 (B0289_RS21920)	1519325..1520551	-	1227	WP_077102140.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17127.73 Da
• Isoelectric Point: 9.8215

>T293456 WP_077102130.1 NZ_LT717701:1515490-1515963 [Mycobacterium terramassiliense]
MAKLSGSIDVPLPPEVAWKHASDLSRYKDWLTIHRVWRSTLPDDIDKGTVVESIVEVKGMYNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLLAKVQPADEGSVVSFDVHLGGPALFGPIGMIVAAALRSDINQSLRNFVRVFTAPDPHTNGDGGVRR

Nucleotide

• Length: 474 bp

>T293456 NZ_LT717701:1515490-1515963 [Mycobacterium terramassiliense]
ATGGCGAAACTATCCGGATCCATCGACGTACCGCTGCCTCCCGAGGTGGCCTGGAAGCACGCCTCCGACCTGTCGCGGTA
CAAGGACTGGCTGACCATCCATCGGGTGTGGCGCAGCACGCTGCCCGACGACATCGACAAGGGGACGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGTACAACCGGATCAAGTGGACGGTCGTGCGCTACAAGCCGCCGGAAGGCATGACGCTCAAC
GGGGATGGCGTCGGCGGGGTCAAGGTCAAGCTGCTGGCCAAGGTTCAACCCGCGGACGAGGGCTCCGTCGTCAGCTTCGA
CGTGCACCTCGGTGGCCCGGCGCTGTTCGGGCCGATCGGCATGATCGTCGCCGCCGCGTTGCGCAGCGACATCAACCAGT
CGCTGCGGAACTTCGTCCGGGTGTTCACCGCCCCCGATCCGCACACGAACGGGGACGGCGGCGTCCGTCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6693.37 Da
• Isoelectric Point: 4.6881

>AT293456 WP_077102128.1 NZ_LT717701:1515297-1515485 [Mycobacterium terramassiliense]
MGFLDKAKDLLAQNADKVETAIDKAGEFVDGRTQGKYSDTIHKVAEEAKKAADSAVQNDPQN

Nucleotide

• Length: 189 bp

>AT293456 NZ_LT717701:1515297-1515485 [Mycobacterium terramassiliense]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGGCGCAAAACGCCGACAAGGTCGAGACCGCGATAGACAAGGCCGGCGA
ATTCGTCGACGGCAGGACGCAGGGAAAGTACTCGGACACCATCCACAAGGTGGCCGAAGAGGCCAAGAAAGCGGCCGATT
CCGCCGTCCAGAACGACCCGCAGAACTGA