Detailed information of TA system TA293452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-DinJ
• Location: 1468345..1468897
• Replicon: chromosome
• Accession: NZ_LT706985
• Organism: Propionimicrobium sp. Marseille-P3275 strain Marseille-P3275T

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CZ356_RS07005
• Protein ID: WP_076389272.1
• Coordinates: 1468571..1468897 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: CZ356_RS07000
• Protein ID: WP_076389271.1
• Coordinates: 1468345..1468581 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CZ356_RS06970	1463689..1464345	-	657	WP_076389268.1	alpha/beta fold hydrolase	-
CZ356_RS06975	1464342..1464935	-	594	WP_076389269.1	DUF1700 domain-containing protein	-
CZ356_RS06980	1464938..1465270	-	333	WP_076389916.1	PadR family transcriptional regulator	-
CZ356_RS06985	1465417..1466043	-	627	WP_197684241.1	recombinase zinc beta ribbon domain-containing protein	-
CZ356_RS09640	1466151..1466315	-	165	WP_156874602.1	hypothetical protein	-
CZ356_RS06990	1466543..1467979	+	1437	WP_076389270.1	putative DNA binding domain-containing protein	-
CZ356_RS06995	1468051..1468200	+	150	Protein_1351	toxin-antitoxin system subunit antitoxin	-
CZ356_RS07000	1468345..1468581	+	237	WP_076389271.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CZ356_RS07005	1468571..1468897	+	327	WP_076389272.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CZ356_RS07010	1469275..1470492	-	1218	WP_076389273.1	DUF4143 domain-containing protein	-
CZ356_RS07015	1470901..1472181	+	1281	WP_076389274.1	DUF4143 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-104)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-51)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11206.96 Da
• Isoelectric Point: 8.7596

>T293452 WP_076389272.1 NZ_LT706985:1468571-1468897 [Propionimicrobium sp. Marseille-P3275]
MRGEIWTVCASGYASKPRPAVIVQADSVVGFDSTIVCLFTTDDSLKGATRVSVKATGGNGLTKDCIVMAEKPVAINKSRL
GEKLGALEAETLSKVGSALRQVFGFGVG

Nucleotide

• Length: 327 bp

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8788.84 Da
• Isoelectric Point: 4.3063

>AT293452 WP_076389271.1 NZ_LT706985:1468345-1468581 [Propionimicrobium sp. Marseille-P3275]
MVQLATRVDDEDGKTFKDLTKRLGTTPADAIRMFVMAFNANRGFPYEVRLSDAQPFESEKEAVNFIDDLATETISDAR

Nucleotide

• Length: 237 bp