Detailed information of TA system TA029345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 392720..393326
• Replicon: chromosome
• Accession: NC_021058
• Organism: Sulfolobus islandicus LAL14/1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M9U4G3
• Locus tag: SIL_RS02130
• Protein ID: WP_012710548.1
• Coordinates: 392720..393082 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UCL5
• Locus tag: SIL_RS02135
• Protein ID: WP_012718013.1
• Coordinates: 393105..393326 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIL_RS02115 (SiL_0428)	388581..389978	-	1398	WP_014512473.1	glycosyltransferase	-
SIL_RS02120 (SiL_0429)	390023..390616	-	594	WP_012718017.1	hypothetical protein	-
SIL_RS02125 (SiL_0430)	390708..392261	+	1554	WP_014512472.1	aldehyde dehydrogenase family protein	-
SIL_RS02130 (SiL_0431)	392720..393082	-	363	WP_012710548.1	type II toxin-antitoxin system VapC family toxin	Toxin
SIL_RS02135 (SiL_0432)	393105..393326	-	222	WP_012718013.1	hypothetical protein	Antitoxin
SIL_RS02140	393792..394128	-	337	Protein_438	transposase	-
SIL_RS02145 (SiL_0433)	394171..395402	-	1232	Protein_439	IS256 family transposase	-
SIL_RS02155	395445..395759	-	315	Protein_440	IS5/IS1182 family transposase	-
SIL_RS02160 (SiL_0434)	395893..396453	-	561	WP_014513534.1	PIG-L deacetylase family protein	-
SIL_RS02165 (SiL_0435)	396458..397603	-	1146	WP_015580772.1	glycosyltransferase family 4 protein	-
SIL_RS02170 (SiL_0436)	397758..398291	+	534	WP_012713047.1	ADP-ribose-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (21-113)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13870.21 Da
• Isoelectric Point: 9.2430

>T29345 WP_012710548.1 NC_021058:c393082-392720 [Sulfolobus islandicus LAL14/1]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Nucleotide

• Length: 363 bp

>T29345 NC_021058:c393082-392720 [Sulfolobus islandicus LAL14/1]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTATTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8952.22 Da
• Isoelectric Point: 4.6475

>AT29345 WP_012718013.1 NC_021058:c393326-393105 [Sulfolobus islandicus LAL14/1]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN

Nucleotide

• Length: 222 bp

>AT29345 NC_021058:c393326-393105 [Sulfolobus islandicus LAL14/1]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA

Structures

Toxin

• AlphaFold DB: M9U4G3

Antitoxin

• AlphaFold DB: M9UCL5