293446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 25510..26048 Replicon plasmid 3
Accession NZ_LT703507
Organism Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag CCZ12_RS30800 Protein ID WP_007172405.1
Coordinates 25791..26048 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag CCZ12_RS30795 Protein ID WP_007172404.1
Coordinates 25510..25794 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ12_RS30775 20643..22163 - 1521 WP_007172379.1 DUF4226 domain-containing protein -
CCZ12_RS30780 22385..23140 - 756 WP_074021258.1 DUF2637 domain-containing protein -
CCZ12_RS30785 23942..24664 + 723 WP_139315444.1 ParA family protein -
CCZ12_RS30790 24667..25428 + 762 WP_023363524.1 hypothetical protein -
CCZ12_RS30795 25510..25794 + 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CCZ12_RS30800 25791..26048 + 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
CCZ12_RS30805 26263..26556 - 294 WP_007172406.1 hypothetical protein -
CCZ12_RS30810 26573..27571 - 999 WP_101930848.1 hypothetical protein -
CCZ12_RS30815 28370..28852 + 483 WP_040624353.1 hypothetical protein -
CCZ12_RS30820 28842..29942 + 1101 WP_007172409.1 tyrosine-type recombinase/integrase -
CCZ12_RS30825 30061..30273 + 213 WP_007172410.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97266 97266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T293446 WP_007172405.1 NZ_LT703507:25791-26048 [Mycobacterium intracellulare subsp. chimaera]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT293446 WP_007172404.1 NZ_LT703507:25510-25794 [Mycobacterium intracellulare subsp. chimaera]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References