293445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 10567..11108 Replicon plasmid 3
Accession NZ_LT703507
Organism Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera

Toxin (Protein)


Gene name parE Uniprot ID D5P595
Locus tag CCZ12_RS30715 Protein ID WP_007172365.1
Coordinates 10567..10860 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A854I1S2
Locus tag CCZ12_RS30720 Protein ID WP_040624378.1
Coordinates 10857..11108 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ12_RS32190 5897..6328 - 432 WP_139315439.1 hypothetical protein -
CCZ12_RS30695 6559..6831 - 273 WP_139315440.1 hypothetical protein -
CCZ12_RS32195 6955..7626 - 672 WP_139315441.1 hypothetical protein -
CCZ12_RS30700 7736..8815 - 1080 WP_007172361.1 hypothetical protein -
CCZ12_RS30705 8930..9628 - 699 WP_139315442.1 hypothetical protein -
CCZ12_RS30710 9642..10349 - 708 WP_139315443.1 hypothetical protein -
CCZ12_RS30715 10567..10860 - 294 WP_007172365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCZ12_RS30720 10857..11108 - 252 WP_040624378.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CCZ12_RS30725 11214..11720 - 507 WP_007172367.1 helix-turn-helix domain-containing protein -
CCZ12_RS30730 12027..12464 + 438 WP_007172368.1 WhiB family transcriptional regulator -
CCZ12_RS30735 12520..13110 + 591 WP_023363514.1 hypothetical protein -
CCZ12_RS32200 13073..13357 + 285 WP_007172369.1 hypothetical protein -
CCZ12_RS30740 13734..15596 + 1863 WP_023363516.1 helicase associated domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97266 97266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.74 Da        Isoelectric Point: 6.9772

>T293445 WP_007172365.1 NZ_LT703507:c10860-10567 [Mycobacterium intracellulare subsp. chimaera]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL

Download         Length: 294 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9203.22 Da        Isoelectric Point: 5.8579

>AT293445 WP_040624378.1 NZ_LT703507:c11108-10857 [Mycobacterium intracellulare subsp. chimaera]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0TBP0

Antitoxin

Source ID Structure
AlphaFold DB A0A854I1S2

References