293444

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 4544868..4545394 Replicon chromosome
Accession NZ_LT703505
Organism Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera

Toxin (Protein)


Gene name Rv0299 Uniprot ID S4ZDZ6
Locus tag CCZ12_RS21090 Protein ID WP_008259048.1
Coordinates 4545092..4545394 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID S4ZFD0
Locus tag CCZ12_RS21085 Protein ID WP_008259047.1
Coordinates 4544868..4545095 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ12_RS21060 4539939..4540865 - 927 WP_042912749.1 MinD/ParA family protein -
CCZ12_RS21065 4541110..4542141 - 1032 WP_042912751.1 6-phosphofructokinase -
CCZ12_RS21070 4542185..4543678 - 1494 WP_042912754.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
CCZ12_RS21075 4543675..4543974 - 300 WP_009952003.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
CCZ12_RS21080 4544074..4544730 + 657 WP_087139897.1 amino acid-binding protein -
CCZ12_RS21085 4544868..4545095 + 228 WP_008259047.1 ribbon-helix-helix protein, CopG family Antitoxin
CCZ12_RS21090 4545092..4545394 + 303 WP_008259048.1 hypothetical protein Toxin
CCZ12_RS21095 4545510..4545818 - 309 WP_008259049.1 hypothetical protein -
CCZ12_RS21100 4545877..4548798 - 2922 WP_014712101.1 MMPL family transporter -
CCZ12_RS21105 4548795..4549199 - 405 WP_008259052.1 hypothetical protein -
CCZ12_RS21110 4549446..4549964 + 519 WP_042912757.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10473.31 Da        Isoelectric Point: 4.5636

>T293444 WP_008259048.1 NZ_LT703505:4545092-4545394 [Mycobacterium intracellulare subsp. chimaera]
MIAPGDIAPRRDTRRDLYVAVLSNAIHLAANTGRVIVCPFIPGKIPDDTMAMVVPLTQPEGTLLPELVQWLPTSALGEPI
GAVSAAALSEAMSIVTALIT

Download         Length: 303 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8173.14 Da        Isoelectric Point: 6.4608

>AT293444 WP_008259047.1 NZ_LT703505:4544868-4545095 [Mycobacterium intracellulare subsp. chimaera]
MAKEKISVTVDAAVLADADSDAKAAGLNRSEMIERALRNEHLRRALHTYTTRTAPALNIDSYAGQVYEANRAADL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4ZDZ6

Antitoxin

Source ID Structure
AlphaFold DB S4ZFD0

References