Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2845789..2846781 | Replicon | chromosome |
| Accession | NZ_LT703505 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A854HPC2 |
| Locus tag | CCZ12_RS13320 | Protein ID | WP_054585353.1 |
| Coordinates | 2846203..2846781 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A854UQX7 |
| Locus tag | CCZ12_RS13315 | Protein ID | WP_054585352.1 |
| Coordinates | 2845789..2846178 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCZ12_RS13295 | 2840940..2841608 | - | 669 | WP_179300141.1 | hypothetical protein | - |
| CCZ12_RS13300 | 2841688..2843205 | + | 1518 | WP_054585349.1 | carboxylesterase/lipase family protein | - |
| CCZ12_RS13305 | 2843224..2845227 | + | 2004 | WP_054585350.1 | phosphotransferase | - |
| CCZ12_RS13310 | 2845224..2845718 | + | 495 | WP_054585351.1 | gluconokinase | - |
| CCZ12_RS13315 | 2845789..2846178 | + | 390 | WP_054585352.1 | hypothetical protein | Antitoxin |
| CCZ12_RS13320 | 2846203..2846781 | + | 579 | WP_054585353.1 | zeta toxin family protein | Toxin |
| CCZ12_RS13325 | 2846792..2847859 | - | 1068 | WP_054585354.1 | DoxX family membrane protein | - |
| CCZ12_RS13330 | 2847955..2848515 | + | 561 | WP_008256422.1 | pyrazinamidase PncA | - |
| CCZ12_RS13335 | 2848515..2849315 | + | 801 | WP_054585355.1 | nuclear transport factor 2 family protein | - |
| CCZ12_RS13340 | 2849327..2849677 | - | 351 | WP_054585356.1 | DoxX family protein | - |
| CCZ12_RS13345 | 2849843..2850814 | + | 972 | WP_054585357.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21127.16 Da Isoelectric Point: 10.7751
>T293443 WP_054585353.1 NZ_LT703505:2846203-2846781 [Mycobacterium intracellulare subsp. chimaera]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
Download Length: 579 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13529.94 Da Isoelectric Point: 5.5559
>AT293443 WP_054585352.1 NZ_LT703505:2845789-2846178 [Mycobacterium intracellulare subsp. chimaera]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854HPC2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854UQX7 |