Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4769861..4770386 Replicon chromosome
Accession NC_021055
Organism Streptomyces sp. PAMC26508

Toxin (Protein)


Gene name relE Uniprot ID A0A4P7DII6
Locus tag F750_RS21315 Protein ID WP_015578584.1
Coordinates 4769861..4770124 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3N6F7F2
Locus tag F750_RS21320 Protein ID WP_015578585.1
Coordinates 4770117..4770386 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F750_RS21285 4765814..4766551 + 738 WP_015578580.1 ROK family protein -
F750_RS21290 4766570..4767184 - 615 WP_014154300.1 hypothetical protein -
F750_RS21295 4767429..4768517 + 1089 WP_014154299.1 redox-regulated ATPase YchF -
F750_RS21300 4768639..4769031 - 393 WP_015578581.1 hypothetical protein -
F750_RS21305 4769031..4769282 - 252 WP_015578582.1 hypothetical protein -
F750_RS21310 4769359..4769550 - 192 Protein_4229 hypothetical protein -
F750_RS21315 4769861..4770124 - 264 WP_015578584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F750_RS21320 4770117..4770386 - 270 WP_015578585.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F750_RS21325 4770781..4771467 - 687 WP_041667870.1 hypothetical protein -
F750_RS21330 4771451..4771888 - 438 WP_015578588.1 hypothetical protein -
F750_RS21335 4771909..4774323 - 2415 WP_015578589.1 DUF1906 domain-containing protein -
F750_RS21340 4774686..4775168 + 483 WP_014154291.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9950.52 Da        Isoelectric Point: 10.4269

>T29344 WP_015578584.1 NC_021055:c4770124-4769861 [Streptomyces sp. PAMC 26508]
VSEYRAVFRPEAQAELRKIPREKALRILTKLTELESAPLGFATTALVSQPERRRLRVGDYRVVYTIDKGELVVWVVHVGH
RSTVYGT

Download         Length: 264 bp

>T29344 NC_021055:c4770124-4769861 [Streptomyces sp. PAMC 26508]
GTGAGTGAGTACCGGGCCGTCTTCCGGCCAGAGGCACAGGCCGAGCTCCGGAAGATCCCTCGCGAAAAGGCCCTACGCAT
CCTGACCAAACTGACCGAGCTGGAGAGCGCCCCCCTCGGCTTTGCCACCACCGCGCTCGTGTCACAGCCGGAACGCCGTC
GGCTGCGGGTCGGTGACTACCGCGTCGTCTACACGATCGACAAGGGAGAGCTCGTGGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTCTACGGCACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10304.81 Da        Isoelectric Point: 4.7473

>AT29344 WP_015578585.1 NC_021055:c4770386-4770117 [Streptomyces sp. PAMC 26508]
MTQPLPIESIRDVRAHLAEVVERADRDDMPTVITRRGKQIAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT29344 NC_021055:c4770386-4770117 [Streptomyces sp. PAMC 26508]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGTGACGTACGTGCACACCTGGCCGAGGTCGTGGAGCGCGCCGATCGAGA
TGACATGCCCACCGTGATCACCCGACGGGGCAAGCAGATTGCCGCTGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAACCGGATCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7DII6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N6F7F2

References