293438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1259518..1260171 Replicon chromosome
Accession NZ_LT703505
Organism Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CCZ12_RS06340 Protein ID WP_008253911.1
Coordinates 1259710..1260171 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID X8A187
Locus tag CCZ12_RS06335 Protein ID WP_009957321.1
Coordinates 1259518..1259706 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ12_RS06325 1255491..1257068 + 1578 WP_042911067.1 serine hydrolase -
CCZ12_RS06330 1257065..1259452 + 2388 WP_042910814.1 cation-translocating P-type ATPase -
CCZ12_RS06335 1259518..1259706 + 189 WP_009957321.1 antitoxin Antitoxin
CCZ12_RS06340 1259710..1260171 + 462 WP_008253911.1 SRPBCC family protein Toxin
CCZ12_RS06345 1260258..1261028 + 771 WP_042910815.1 VOC family protein -
CCZ12_RS06350 1261102..1261536 + 435 WP_008253914.1 hypothetical protein -
CCZ12_RS06355 1261541..1262029 - 489 WP_036454690.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
CCZ12_RS06360 1262029..1263543 - 1515 WP_042910816.1 carotenoid oxygenase family protein -
CCZ12_RS06365 1263546..1264766 - 1221 WP_042910817.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16639.20 Da        Isoelectric Point: 8.5617

>T293438 WP_008253911.1 NZ_LT703505:1259710-1260171 [Mycobacterium intracellulare subsp. chimaera]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Download         Length: 462 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6698.30 Da        Isoelectric Point: 4.4702

>AT293438 WP_009957321.1 NZ_LT703505:1259518-1259706 [Mycobacterium intracellulare subsp. chimaera]
MGFLDKAKDLLSQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKAAGAADTGDQQN

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X8A187

References