293436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 973253..973920 Replicon chromosome
Accession NZ_LT703505
Organism Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag CCZ12_RS04860 Protein ID WP_007168407.1
Coordinates 973528..973920 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag CCZ12_RS04855 Protein ID WP_007168406.1
Coordinates 973253..973528 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ12_RS32325 968757..969083 - 327 WP_033711234.1 hypothetical protein -
CCZ12_RS04830 969073..969306 - 234 Protein_942 transposase -
CCZ12_RS04835 969324..970535 - 1212 Protein_943 ISL3 family transposase -
CCZ12_RS04840 970674..971306 - 633 Protein_944 DDE-type integrase/transposase/recombinase -
CCZ12_RS31660 971300..971389 - 90 Protein_945 SDR family oxidoreductase -
CCZ12_RS04845 971442..972145 - 704 Protein_946 histidine phosphatase family protein -
CCZ12_RS04850 972228..973100 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
CCZ12_RS04855 973253..973528 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CCZ12_RS04860 973528..973920 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
CCZ12_RS04865 974068..975227 - 1160 Protein_950 trehalose-phosphatase -
CCZ12_RS04870 975269..976607 - 1339 Protein_951 DUF1298 domain-containing protein -
CCZ12_RS31665 976869..976991 - 123 Protein_952 IS1595 family transposase -
CCZ12_RS04880 977327..978661 + 1335 Protein_953 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T293436 WP_007168407.1 NZ_LT703505:973528-973920 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT293436 WP_007168406.1 NZ_LT703505:973253-973528 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References