293434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 288019..288917 Replicon chromosome
Accession NZ_LT703505
Organism Mycobacterium intracellulare subsp. chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera

Toxin (Protein)


Gene name mbcT Uniprot ID A0A7I9ZD82
Locus tag CCZ12_RS01395 Protein ID WP_042910420.1
Coordinates 288019..288579 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID A0A7I9ZDJ0
Locus tag CCZ12_RS01400 Protein ID WP_042910421.1
Coordinates 288576..288917 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ12_RS01375 284899..285384 + 486 WP_051445817.1 hypothetical protein -
CCZ12_RS31590 285656..285892 + 237 WP_142383091.1 hypothetical protein -
CCZ12_RS01385 286552..286734 - 183 WP_042910451.1 antitoxin VbhA family protein -
CCZ12_RS01390 286838..287842 - 1005 WP_042910419.1 tyrosine-type recombinase/integrase -
CCZ12_RS01395 288019..288579 - 561 WP_042910420.1 RES domain-containing protein Toxin
CCZ12_RS01400 288576..288917 - 342 WP_042910421.1 DUF2384 domain-containing protein Antitoxin
CCZ12_RS01405 289004..290157 + 1154 Protein_274 hypothetical protein -
CCZ12_RS01410 290335..291329 - 995 Protein_275 IS481 family transposase -
CCZ12_RS01415 292365..292997 - 633 WP_042910422.1 CAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20501.00 Da        Isoelectric Point: 5.8540

>T293434 WP_042910420.1 NZ_LT703505:c288579-288019 [Mycobacterium intracellulare subsp. chimaera]
VSDALDEGLVQRIDACGTTPWSGTCYRYTTAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAKACMVEVERAANAASTT
AIKMLEAAYRLHHIQVEELNVLDLRTPESRDAVGLDDDDVYGDDWSACQAVGHTAWFLHMQGILVPAAGGIGLVISAYEQ
RTRPRQLHLRHSENLTPALYTQYRSS

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12612.51 Da        Isoelectric Point: 4.8483

>AT293434 WP_042910421.1 NZ_LT703505:c288917-288576 [Mycobacterium intracellulare subsp. chimaera]
MAMNALASTVSSAIERLGLTYEEVGDIVEASPRSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANMWMFSPN
RLLEHRKPADLIRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I9ZD82

Antitoxin

Source ID Structure
AlphaFold DB A0A7I9ZDJ0

References