Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4403880..4405138 Replicon chromosome
Accession NZ_LT673656
Organism Pseudomonas aeruginosa isolate PcyII-10

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PERCYII10_RS20710 Protein ID WP_003112528.1
Coordinates 4403880..4404635 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PERCYII10_RS20715 Protein ID WP_003086329.1
Coordinates 4404770..4405138 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII10_RS20700 4399053..4401596 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PERCYII10_RS20705 4401751..4403112 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PERCYII10_RS20710 4403880..4404635 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PERCYII10_RS20715 4404770..4405138 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PERCYII10_RS20720 4405211..4406497 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PERCYII10_RS20725 4406553..4408142 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PERCYII10_RS20730 4408221..4408697 + 477 WP_003140638.1 hypothetical protein -
PERCYII10_RS29895 4408700..4408975 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T293432 WP_003112528.1 NZ_LT673656:c4404635-4403880 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT293432 WP_003086329.1 NZ_LT673656:c4405138-4404770 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References