Detailed information of TA system TA029343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2379995..2380632
• Replicon: chromosome
• Accession: NC_021055
• Organism: Streptomyces sp. PAMC26508

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F750_RS10565
• Protein ID: WP_015577067.1
• Coordinates: 2379995..2380402 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A212SI58
• Locus tag: F750_RS10570
• Protein ID: WP_015577068.1
• Coordinates: 2380399..2380632 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F750_RS10550	2375823..2378498	+	2676	WP_015577064.1	S8 family serine peptidase	-
F750_RS10555	2378632..2378982	-	351	WP_041668196.1	hypothetical protein	-
F750_RS10565	2379995..2380402	-	408	WP_015577067.1	PIN domain nuclease	Toxin
F750_RS10570	2380399..2380632	-	234	WP_015577068.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
F750_RS10590	2381619..2381921	+	303	WP_015577069.1	YtxH domain-containing protein	-
F750_RS10595	2382004..2383449	+	1446	WP_014156407.1	sugar kinase	-
F750_RS10600	2383586..2385319	+	1734	WP_015577070.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-45)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15000.00 Da
• Isoelectric Point: 6.3974

>T29343 WP_015577067.1 NC_021055:c2380402-2379995 [Streptomyces sp. PAMC 26508]
VITYLLDTSALWHLFRTPGALRPWEGHIAAGVFHICEPTRAEFLFSATSPADRDELAEELDDLCHLAPVPKSAWRWVDTA
QYKLTQRGQHRAAGAIDLLVCATAVHHGHTVLHVDNDFATVGAVLKEVQQRDVRA

Nucleotide

• Length: 408 bp

>T29343 NC_021055:c2380402-2379995 [Streptomyces sp. PAMC 26508]
GTGATCACATACCTCCTCGACACGTCCGCCCTCTGGCACCTCTTCCGTACGCCGGGGGCACTGCGTCCCTGGGAGGGGCA
CATCGCTGCCGGTGTGTTCCATATCTGCGAGCCCACGAGGGCGGAGTTCCTCTTCTCGGCCACAAGCCCGGCTGATCGGG
ACGAGTTGGCCGAGGAGCTGGATGACCTCTGTCATCTCGCCCCGGTTCCCAAGAGTGCGTGGCGCTGGGTCGACACCGCG
CAGTACAAGCTCACCCAGCGGGGGCAGCATCGTGCCGCCGGAGCCATCGACCTCCTGGTGTGTGCGACGGCGGTCCATCA
CGGTCACACGGTGCTGCACGTGGACAACGACTTCGCCACGGTGGGGGCGGTCCTGAAGGAAGTGCAGCAACGAGACGTAC
GCGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8304.43 Da
• Isoelectric Point: 7.0151

>AT29343 WP_015577068.1 NC_021055:c2380632-2380399 [Streptomyces sp. PAMC 26508]
MSVTQVDLDDEALAEAMRLMGVSTKKETVNGALRDYVARIKRLEAAEKLAARGERGEFEAAAAAHAAAKQARRAAFE

Nucleotide

• Length: 234 bp

>AT29343 NC_021055:c2380632-2380399 [Streptomyces sp. PAMC 26508]
ATGTCTGTGACCCAGGTCGATCTCGATGATGAGGCGCTGGCTGAGGCGATGCGGCTCATGGGTGTCTCGACGAAGAAGGA
GACGGTGAACGGGGCCCTACGGGACTATGTGGCGCGCATCAAGCGGCTGGAGGCTGCCGAGAAGCTGGCCGCGAGGGGTG
AGCGGGGCGAGTTCGAGGCTGCGGCTGCGGCGCATGCAGCGGCCAAGCAGGCCCGGCGGGCAGCCTTCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A212SI58