Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2379995..2380632 Replicon chromosome
Accession NC_021055
Organism Streptomyces sp. PAMC26508

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F750_RS10565 Protein ID WP_015577067.1
Coordinates 2379995..2380402 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A212SI58
Locus tag F750_RS10570 Protein ID WP_015577068.1
Coordinates 2380399..2380632 (-) Length 78 a.a.

Genomic Context

F750_RS10550F750_RS10590F750_RS10595F750_RS10600F750_RS10555F750_RS10565F750_RS10570
Location: 2375823..2378498 (2676 bp)
Type: Others
Protein ID: WP_015577064.1
Location: 2381619..2381921 (303 bp)
Type: Others
Protein ID: WP_015577069.1
Location: 2382004..2383449 (1446 bp)
Type: Others
Protein ID: WP_014156407.1
Location: 2383586..2385319 (1734 bp)
Type: Others
Protein ID: WP_015577070.1
Location: 2378632..2378982 (351 bp)
Type: Others
Protein ID: WP_041668196.1
Location: 2379995..2380402 (408 bp)
Type: Toxin
Protein ID: WP_015577067.1
Location: 2380399..2380632 (234 bp)
Type: Antitoxin
Protein ID: WP_015577068.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F750_RS105502375823..2378498+2676WP_015577064.1S8 family serine peptidase-
F750_RS105552378632..2378982-351WP_041668196.1hypothetical protein-
F750_RS105652379995..2380402-408WP_015577067.1PIN domain nucleaseToxin
F750_RS105702380399..2380632-234WP_015577068.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
F750_RS105902381619..2381921+303WP_015577069.1YtxH domain-containing protein-
F750_RS105952382004..2383449+1446WP_014156407.1sugar kinase-
F750_RS106002383586..2385319+1734WP_015577070.1ABC transporter ATP-binding protein/permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15000.00 Da        Isoelectric Point: 6.3974

>T29343 WP_015577067.1 NC_021055:c2380402-2379995 [Streptomyces sp. PAMC 26508]
VITYLLDTSALWHLFRTPGALRPWEGHIAAGVFHICEPTRAEFLFSATSPADRDELAEELDDLCHLAPVPKSAWRWVDTA
QYKLTQRGQHRAAGAIDLLVCATAVHHGHTVLHVDNDFATVGAVLKEVQQRDVRA

Download         Length: 408 bp

>T29343 NC_021055:c2380402-2379995 [Streptomyces sp. PAMC 26508]
GTGATCACATACCTCCTCGACACGTCCGCCCTCTGGCACCTCTTCCGTACGCCGGGGGCACTGCGTCCCTGGGAGGGGCA
CATCGCTGCCGGTGTGTTCCATATCTGCGAGCCCACGAGGGCGGAGTTCCTCTTCTCGGCCACAAGCCCGGCTGATCGGG
ACGAGTTGGCCGAGGAGCTGGATGACCTCTGTCATCTCGCCCCGGTTCCCAAGAGTGCGTGGCGCTGGGTCGACACCGCG
CAGTACAAGCTCACCCAGCGGGGGCAGCATCGTGCCGCCGGAGCCATCGACCTCCTGGTGTGTGCGACGGCGGTCCATCA
CGGTCACACGGTGCTGCACGTGGACAACGACTTCGCCACGGTGGGGGCGGTCCTGAAGGAAGTGCAGCAACGAGACGTAC
GCGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8304.43 Da        Isoelectric Point: 7.0151

>AT29343 WP_015577068.1 NC_021055:c2380632-2380399 [Streptomyces sp. PAMC 26508]
MSVTQVDLDDEALAEAMRLMGVSTKKETVNGALRDYVARIKRLEAAEKLAARGERGEFEAAAAAHAAAKQARRAAFE

Download         Length: 234 bp

>AT29343 NC_021055:c2380632-2380399 [Streptomyces sp. PAMC 26508]
ATGTCTGTGACCCAGGTCGATCTCGATGATGAGGCGCTGGCTGAGGCGATGCGGCTCATGGGTGTCTCGACGAAGAAGGA
GACGGTGAACGGGGCCCTACGGGACTATGTGGCGCGCATCAAGCGGCTGGAGGCTGCCGAGAAGCTGGCCGCGAGGGGTG
AGCGGGGCGAGTTCGAGGCTGCGGCTGCGGCGCATGCAGCGGCCAAGCAGGCCCGGCGGGCAGCCTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A212SI58

References