293429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142222..142727 Replicon chromosome
Accession NZ_LT673656
Organism Pseudomonas aeruginosa isolate PcyII-10

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PERCYII10_RS00640 Protein ID WP_003083773.1
Coordinates 142222..142503 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PERCYII10_RS00645 Protein ID WP_003083775.1
Coordinates 142500..142727 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII10_RS00615 137473..138822 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PERCYII10_RS00620 138871..139557 + 687 WP_003083762.1 FadR family transcriptional regulator -
PERCYII10_RS00625 139658..140392 + 735 WP_003101224.1 GntR family transcriptional regulator -
PERCYII10_RS00630 140596..140982 + 387 WP_014602345.1 aegerolysin family protein -
PERCYII10_RS00635 141014..141922 - 909 WP_016561475.1 LysR family transcriptional regulator -
PERCYII10_RS00640 142222..142503 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PERCYII10_RS00645 142500..142727 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PERCYII10_RS00650 142903..143523 - 621 WP_003101226.1 hypothetical protein -
PERCYII10_RS00655 143624..144124 + 501 WP_003112629.1 LEA type 2 family protein -
PERCYII10_RS00660 144197..144538 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PERCYII10_RS00665 144620..146047 - 1428 WP_003083784.1 GABA permease -
PERCYII10_RS00670 146216..147709 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T293429 WP_003083773.1 NZ_LT673656:c142503-142222 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT293429 WP_003083775.1 NZ_LT673656:c142727-142500 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References