Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2129015..2129529 Replicon chromosome
Accession NZ_LT671859
Organism Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag EDCC5055_RS11115 Protein ID WP_000581792.1
Coordinates 2129015..2129224 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag EDCC5055_RS11120 Protein ID WP_000138932.1
Coordinates 2129236..2129529 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDCC5055_RS11095 2124523..2125881 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EDCC5055_RS11100 2125896..2126966 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
EDCC5055_RS11105 2127284..2128486 + 1203 WP_001109939.1 rod shape-determining protein RodA -
EDCC5055_RS11110 2128750..2128887 - 138 WP_000828354.1 hypothetical protein -
EDCC5055_RS11115 2129015..2129224 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
EDCC5055_RS11120 2129236..2129529 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
EDCC5055_RS11125 2129695..2131179 + 1485 WP_000571549.1 cardiolipin synthase -
EDCC5055_RS11130 2131207..2131854 + 648 WP_001187629.1 HD domain-containing protein -
EDCC5055_RS11150 2132667..2133539 - 873 WP_000725802.1 membrane protein insertase YidC -
EDCC5055_RS11155 2133625..2134266 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T293423 WP_000581792.1 NZ_LT671859:c2129224-2129015 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT293423 WP_000138932.1 NZ_LT671859:c2129529-2129236 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References