Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2109259..2109788 Replicon chromosome
Accession NZ_LT671859
Organism Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EDCC5055_RS11025 Protein ID WP_000621175.1
Coordinates 2109259..2109621 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EDCC5055_RS11030 Protein ID WP_000948331.1
Coordinates 2109618..2109788 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDCC5055_RS11000 2106238..2107008 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
EDCC5055_RS11005 2106983..2107462 - 480 WP_001190829.1 anti-sigma B factor RsbW -
EDCC5055_RS11010 2107464..2107790 - 327 WP_001052491.1 anti-sigma factor antagonist -
EDCC5055_RS11015 2107909..2108910 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EDCC5055_RS11025 2109259..2109621 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EDCC5055_RS11030 2109618..2109788 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EDCC5055_RS11035 2109873..2111021 - 1149 WP_001281145.1 alanine racemase -
EDCC5055_RS11040 2111087..2111446 - 360 WP_000581200.1 holo-ACP synthase -
EDCC5055_RS11045 2111450..2111941 - 492 WP_001205910.1 PH domain-containing protein -
EDCC5055_RS11050 2111928..2113511 - 1584 WP_001294626.1 PH domain-containing protein -
EDCC5055_RS11055 2113504..2113983 - 480 WP_001287088.1 hypothetical protein -
EDCC5055_RS11060 2114191..2114751 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T293422 WP_000621175.1 NZ_LT671859:c2109621-2109259 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT293422 WP_000948331.1 NZ_LT671859:c2109788-2109618 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References