Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1582719..1583387 Replicon draft genome
Accession NC_021028
Organism Streptococcus pneumoniae SPN034183

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPN034183_RS08460 Protein ID WP_001132285.1
Coordinates 1583208..1583387 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag SPN034183_RS08455 Protein ID WP_000961812.1
Coordinates 1582719..1583171 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPN034183_RS08430 1578609..1579352 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPN034183_RS08435 1579354..1580304 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
SPN034183_RS08440 1580442..1580870 - 429 WP_000418157.1 NUDIX hydrolase -
SPN034183_RS08445 1580851..1581939 - 1089 WP_000719712.1 M50 family metallopeptidase -
SPN034183_RS08450 1581958..1582428 - 471 WP_000257088.1 DUF3013 family protein -
SPN034183_RS08455 1582719..1583171 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPN034183_RS08460 1583208..1583387 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPN034183_RS08465 1583524..1583772 - 249 WP_000797237.1 hypothetical protein -
SPN034183_RS08470 1583762..1584001 - 240 WP_000818079.1 hypothetical protein -
SPN034183_RS08475 1584271..1585542 + 1272 WP_001113213.1 replication-associated recombination protein A -
SPN034183_RS08485 1585962..1587089 - 1128 WP_000323403.1 site-specific integrase -
SPN034183_RS08490 1587091..1587273 - 183 WP_000655518.1 DUF3173 domain-containing protein -
SPN034183_RS08495 1587289..1588332 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T29342 WP_001132285.1 NC_021028:c1583387-1583208 [Streptococcus pneumoniae SPN034183]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T29342 NC_021028:c1583387-1583208 [Streptococcus pneumoniae SPN034183]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT29342 WP_000961812.1 NC_021028:c1583171-1582719 [Streptococcus pneumoniae SPN034183]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT29342 NC_021028:c1583171-1582719 [Streptococcus pneumoniae SPN034183]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGCTAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References