Detailed information of TA system TA293413

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 727653..729073
• Replicon: chromosome
• Accession: NZ_LT635475
• Organism: Ezakiella massiliensis strain Marseille-P2951T

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: BQ4440_RS03545
• Protein ID: WP_075574052.1
• Coordinates: 727653..728492 (-)
• Length: 280 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: BQ4440_RS03550
• Protein ID: WP_173651641.1
• Coordinates: 728489..729073 (-)
• Length: 195 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BQ4440_RS03520	722962..723420	-	459	WP_075574047.1	GNAT family N-acetyltransferase	-
BQ4440_RS03525	723432..724076	-	645	WP_075574048.1	cupin domain-containing protein	-
BQ4440_RS03530	724257..725639	+	1383	WP_075574049.1	sodium:solute symporter	-
BQ4440_RS03535	725641..726552	+	912	WP_075574050.1	hypothetical protein	-
BQ4440_RS03540	726618..727433	-	816	WP_075574051.1	pirin family protein	-
BQ4440_RS03545	727653..728492	-	840	WP_075574052.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BQ4440_RS03550	728489..729073	-	585	WP_173651641.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
BQ4440_RS03555	729189..730070	-	882	WP_083427731.1	DegV family protein	-
BQ4440_RS03560	730057..731448	-	1392	WP_075574054.1	MATE family efflux transporter	-
BQ4440_RS03565	731600..732529	-	930	WP_075574055.1	2-keto-3-deoxygluconate permease	-
BQ4440_RS03570	732601..733599	-	999	WP_075574056.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
BQ4440_RS03575	733593..733973	-	381	WP_075574057.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-267)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (11-48)

Sequences

Toxin

Protein

• Length: 280 a.a.
• Molecular weight: 32388.74 Da
• Isoelectric Point: 4.9178

>T293413 WP_075574052.1 NZ_LT635475:c728492-727653 [Ezakiella massiliensis]
MNKNKLRDICLNISEETGLSFNSIQTHYFLESILKRIGESDERENFIFKGGFLLSNVIGIGSRSTVDIDFSIKNFSLTEE
NIKQKFEKILEANSNSEIIYKIKNIEKIKDQDEYGGFRIKILCKLDNIELTVPLDIATGDPITGGEIVYEYKSIFSDESI
NICAYNIESILAEKLHTIYSLGSYTSRSKDFYDVYALYKYEEANIDFKKLSQACINTFKYRQTIYSPSEIINTFELIRTD
EQVKKRWDNYQRKNAYAQGIAFDDIIDQAIELVKKMERN

Nucleotide

• Length: 840 bp

Antitoxin

Protein

• Length: 195 a.a.
• Molecular weight: 23083.75 Da
• Isoelectric Point: 8.8354

>AT293413 WP_173651641.1 NZ_LT635475:c729073-728489 [Ezakiella massiliensis]
ISKDINNKIKEKGGIITSEDLRVAEIPTVYLSRMVEDDKLIRVDRGIYIDKNGDYDEYYFFNKRYKVPVFSYMSALYIHG
LSDIIPQKMEVTVYSGYNAHRFKDYVDVNYSKKDIYELGITYKDSIYGNPLKVYNIDKTICDLIKKREEMDAEVFSKALK
KYIAHEEKDLKQLYYYAKKMKIYEKVQKLMELML

Nucleotide

• Length: 585 bp