Detailed information of TA system TA293410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2186997..2188718
• Replicon: chromosome
• Accession: NZ_LT632617
• Organism: Legionella pneumophila strain ST42 isolate ST42

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: BT137_RS10035
• Protein ID: WP_038839099.1
• Coordinates: 2186997..2187929 (-)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A128I8L5
• Locus tag: BT137_RS10040
• Protein ID: WP_015444253.1
• Coordinates: 2187933..2188718 (-)
• Length: 262 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BT137_RS10010	2182556..2182909	-	354	WP_015444259.1	conjugal transfer transcriptional regulator TraJ	-
BT137_RS10015	2183303..2183647	+	345	WP_015444258.1	TraK family protein	-
BT137_RS10020	2183647..2184372	+	726	WP_015444257.1	IncP-type DNA transfer protein TraL	-
BT137_RS10025	2184372..2184809	+	438	WP_015444256.1	conjugal transfer protein TraM	-
BT137_RS10030	2184924..2186864	+	1941	WP_038839098.1	DUF2779 domain-containing protein	-
BT137_RS10035	2186997..2187929	-	933	WP_038839099.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BT137_RS10040	2187933..2188718	-	786	WP_015444253.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
BT137_RS10045	2189380..2189589	+	210	WP_014842095.1	cold-shock protein	-
BT137_RS10050	2189830..2191236	+	1407	WP_038839104.1	ATP-dependent RNA helicase DbpA	-
BT137_RS10055	2191393..2192304	+	912	WP_038839106.1	cation diffusion facilitator family transporter	-
BT137_RS10060	2192576..2192977	-	402	WP_038839107.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2113699..2189141	75442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-264)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (97-254)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35330.14 Da
• Isoelectric Point: 6.8643

>T293410 WP_038839099.1 NZ_LT632617:c2187929-2186997 [Legionella pneumophila]
MNKQSPYYKQVLLLIRLIPLVEKETCFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPREIALANVRNALAGIAANINKI
PDLNAVLQDNKPDEMRIIVEDHSSLNRGTQIKIEVSPVARGTLLPPVELDVVASVENEFGFASMKVVSLPDLYGGKLCAA
LDRQHPRDLFDVKVLLENQKIDRELFNGFLTYLLSHKRPISEIMNPRWKDITQVFEREFKGMTAEPVTLEELTAIPGKMI
QGLKDNFTQQDYDFLVSFKRGEPEWSLACSDQIQYLPAVQWKLLNIRKMPKQKLMDSVSLLQRTMGHWLN

Nucleotide

• Length: 933 bp

Antitoxin

Protein

• Length: 262 a.a.
• Molecular weight: 29773.22 Da
• Isoelectric Point: 9.4457

>AT293410 WP_015444253.1 NZ_LT632617:c2188718-2187933 [Legionella pneumophila]
MSSKINWLLNNIASGEILLQSWLSSHGITPQLARKYCQSQWLVKLGVGVYYRAGRKPRWQNAVYCLQNQSRYMIHLAGLT
SLAQQGKSHYLQFAPDSIWINVQAKTILPKWFKNFPELVISDELIPNWEIIKTSKLNAQDENDLTTIEVDGIKLKASNQE
LAAFEVLEAVPSTLSFEHAAELFQGLVNLSPRKVEHILKRSGSIQTNRLFLFLGHFYKHPWAERVNESLINLGAGKRQIV
PDGKLEKQYQITVPEQFISSD

Nucleotide

• Length: 786 bp

Structures

Antitoxin

• AlphaFold DB: A0A128I8L5