Detailed information of TA system TA293408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2371392..2373113
• Replicon: chromosome
• Accession: NZ_LT632616
• Organism: Legionella pneumophila strain ST37 isolate ST37

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: H044120014_RS10840
• Protein ID: WP_038839099.1
• Coordinates: 2371392..2372324 (-)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A128I8L5
• Locus tag: H044120014_RS10845
• Protein ID: WP_015444253.1
• Coordinates: 2372328..2373113 (-)
• Length: 262 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H044120014_RS10815	2366951..2367304	-	354	WP_015444259.1	conjugal transfer transcriptional regulator TraJ	-
H044120014_RS10820	2367698..2368042	+	345	WP_015444258.1	TraK family protein	-
H044120014_RS10825	2368042..2368767	+	726	WP_015444257.1	IncP-type DNA transfer protein TraL	-
H044120014_RS10830	2368767..2369204	+	438	WP_015444256.1	conjugal transfer protein TraM	-
H044120014_RS10835	2369319..2371259	+	1941	WP_038839098.1	DUF2779 domain-containing protein	-
H044120014_RS10840	2371392..2372324	-	933	WP_038839099.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H044120014_RS10845	2372328..2373113	-	786	WP_015444253.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
H044120014_RS10850	2373598..2374602	-	1005	WP_010947770.1	site-specific integrase	-
H044120014_RS10855	2374515..2374817	-	303	WP_010947771.1	helix-turn-helix domain-containing protein	-
H044120014_RS10865	2375227..2375850	+	624	WP_010947772.1	helix-turn-helix domain-containing protein	-
H044120014_RS10870	2375847..2376053	-	207	WP_021436844.1	hypothetical protein	-
H044120014_RS10875	2376214..2377521	+	1308	WP_010947773.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2263562..2437742	174180

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-264)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (97-254)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35330.14 Da
• Isoelectric Point: 6.8643

>T293408 WP_038839099.1 NZ_LT632616:c2372324-2371392 [Legionella pneumophila]
MNKQSPYYKQVLLLIRLIPLVEKETCFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPREIALANVRNALAGIAANINKI
PDLNAVLQDNKPDEMRIIVEDHSSLNRGTQIKIEVSPVARGTLLPPVELDVVASVENEFGFASMKVVSLPDLYGGKLCAA
LDRQHPRDLFDVKVLLENQKIDRELFNGFLTYLLSHKRPISEIMNPRWKDITQVFEREFKGMTAEPVTLEELTAIPGKMI
QGLKDNFTQQDYDFLVSFKRGEPEWSLACSDQIQYLPAVQWKLLNIRKMPKQKLMDSVSLLQRTMGHWLN

Nucleotide

• Length: 933 bp

Antitoxin

Protein

• Length: 262 a.a.
• Molecular weight: 29773.22 Da
• Isoelectric Point: 9.4457

>AT293408 WP_015444253.1 NZ_LT632616:c2373113-2372328 [Legionella pneumophila]
MSSKINWLLNNIASGEILLQSWLSSHGITPQLARKYCQSQWLVKLGVGVYYRAGRKPRWQNAVYCLQNQSRYMIHLAGLT
SLAQQGKSHYLQFAPDSIWINVQAKTILPKWFKNFPELVISDELIPNWEIIKTSKLNAQDENDLTTIEVDGIKLKASNQE
LAAFEVLEAVPSTLSFEHAAELFQGLVNLSPRKVEHILKRSGSIQTNRLFLFLGHFYKHPWAERVNESLINLGAGKRQIV
PDGKLEKQYQITVPEQFISSD

Nucleotide

• Length: 786 bp

Structures

Antitoxin

• AlphaFold DB: A0A128I8L5