Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2735931..2737387 Replicon chromosome
Accession NZ_LT632615
Organism Legionella pneumophila strain ST23 isolate ST23

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag BQ6063_RS12500 Protein ID WP_061818962.1
Coordinates 2735931..2736782 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag BQ6063_RS12505 Protein ID WP_061401188.1
Coordinates 2736779..2737387 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ6063_RS12465 2731115..2731468 - 354 WP_061818960.1 conjugal transfer transcriptional regulator TraJ -
BQ6063_RS12470 2731893..2732237 + 345 WP_014842348.1 TraK family protein -
BQ6063_RS12475 2732237..2732962 + 726 WP_014842349.1 conjugal transfer protein TraL -
BQ6063_RS12480 2732962..2733402 + 441 WP_042754801.1 conjugal transfer protein TraM -
BQ6063_RS12485 2733567..2735024 + 1458 WP_061818961.1 putative DNA binding domain-containing protein -
BQ6063_RS12490 2735343..2735423 - 81 WP_072356411.1 transposase -
BQ6063_RS12495 2735432..2735851 + 420 Protein_2413 DUF2779 domain-containing protein -
BQ6063_RS12500 2735931..2736782 - 852 WP_061818962.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BQ6063_RS12505 2736779..2737387 - 609 WP_061401188.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
BQ6063_RS12510 2737895..2738296 + 402 WP_061818963.1 hypothetical protein -
BQ6063_RS12520 2739063..2740211 + 1149 WP_014842362.1 outer membrane beta-barrel protein -
BQ6063_RS12525 2740241..2741359 + 1119 WP_061818964.1 DUF3494 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31750.65 Da        Isoelectric Point: 6.2785

>T293406 WP_061818962.1 NZ_LT632615:c2736782-2735931 [Legionella pneumophila]
MTKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYSDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANSRLKDYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22989.06 Da        Isoelectric Point: 9.6557

>AT293406 WP_061401188.1 NZ_LT632615:c2737387-2736779 [Legionella pneumophila]
MKIEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References