Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT2-ataR/DUF1778(antitoxin)
Location 994755..995526 Replicon chromosome
Accession NZ_LT630450
Organism Desulfovibrio piger strain FI11049 isolate FI11049

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1K1LDK2
Locus tag DESPIGER_RS04715 Protein ID WP_072333712.1
Coordinates 994755..995255 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A1K1LDM7
Locus tag DESPIGER_RS04720 Protein ID WP_072333715.1
Coordinates 995257..995526 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DESPIGER_RS12625 990232..992427 + 2196 WP_083575304.1 SDR family NAD(P)-dependent oxidoreductase -
DESPIGER_RS04710 992417..993964 + 1548 WP_072333709.1 sulfatase-like hydrolase/transferase -
DESPIGER_RS12880 994207..994614 + 408 WP_156831637.1 helix-turn-helix domain-containing protein -
DESPIGER_RS04715 994755..995255 - 501 WP_072333712.1 GNAT family N-acetyltransferase Toxin
DESPIGER_RS04720 995257..995526 - 270 WP_072333715.1 DUF1778 domain-containing protein Antitoxin
DESPIGER_RS04725 995655..995924 - 270 WP_072333718.1 hypothetical protein -
DESPIGER_RS04730 995928..996128 - 201 WP_072333720.1 hypothetical protein -
DESPIGER_RS13080 996984..997247 - 264 WP_162273851.1 hypothetical protein -
DESPIGER_RS04735 997585..1000053 + 2469 WP_072333723.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 977464..1003604 26140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(8-82)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18135.16 Da        Isoelectric Point: 10.1489

>T293398 WP_072333712.1 NZ_LT630450:c995255-994755 [Desulfovibrio piger]
MKISAPCHLEAHHHLESFCCGESLLDTWLKTRARKNEASGASRTYVITRSNDVIGYYSLAVGSVSHALVPGRIRRNMPDP
IPVMLLARLAVDTSLQGQGIGRALLRDAILRTEQAAHIAGIRAILVHALHERAKVFYKGCGFTPSPINELTLMLPLSVVR
ASMGSR

Download         Length: 501 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9726.04 Da        Isoelectric Point: 4.9721

>AT293398 WP_072333715.1 NZ_LT630450:c995526-995257 [Desulfovibrio piger]
MSTATEVINVRIPAAQKALIDSAAQLLGKSRTAFILDLAVRHAEDVLAEKTHFQLSSEQWDAFTQALDTPVRPDPALAQL
LNTSAPWDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1K1LDK2

Antitoxin

Source ID Structure
AlphaFold DB A0A1K1LDM7

References