Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 650022..650539 Replicon chromosome
Accession NZ_LT630450
Organism Desulfovibrio piger strain FI11049 isolate FI11049

Toxin (Protein)


Gene name relE Uniprot ID A0A1K1LCT7
Locus tag DESPIGER_RS03205 Protein ID WP_072332989.1
Coordinates 650279..650539 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B6WT68
Locus tag DESPIGER_RS03200 Protein ID WP_006005864.1
Coordinates 650022..650276 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DESPIGER_RS03175 645266..646144 - 879 WP_083575266.1 phosphonate ABC transporter ATP-binding protein -
DESPIGER_RS03185 646553..646780 - 228 WP_156831621.1 hypothetical protein -
DESPIGER_RS03190 647345..648838 - 1494 WP_072332983.1 polyphosphate:AMP phosphotransferase -
DESPIGER_RS03195 649021..649320 - 300 WP_072332986.1 hypothetical protein -
DESPIGER_RS03200 650022..650276 + 255 WP_006005864.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DESPIGER_RS03205 650279..650539 + 261 WP_072332989.1 Txe/YoeB family addiction module toxin Toxin
DESPIGER_RS12800 650783..651112 + 330 WP_156831622.1 hypothetical protein -
DESPIGER_RS03210 651105..652559 + 1455 WP_162273848.1 His-Xaa-Ser system radical SAM maturase HxsB -
DESPIGER_RS03215 652546..653682 + 1137 WP_083575267.1 His-Xaa-Ser system radical SAM maturase HxsC -
DESPIGER_RS13150 653679..653930 + 252 WP_156831623.1 hypothetical protein -
DESPIGER_RS03220 654111..654454 + 344 Protein_613 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 649021..659714 10693
- flank IS/Tn - - 654111..654386 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10384.89 Da        Isoelectric Point: 7.8171

>T293396 WP_072332989.1 NZ_LT630450:650279-650539 [Desulfovibrio piger]
MLLTWTPQAWEDYLYWQATDKRTVKRINELLRDALRNPFEGLGKPEPLRFDLAGCWSRRINQEDRLVYRLDEQGAALIVL
QCRYHY

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9422.62 Da        Isoelectric Point: 5.5169

>AT293396 WP_006005864.1 NZ_LT630450:650022-650276 [Desulfovibrio piger]
MSQAITYTEARQNLAETMNRVCDHHEPVIITRQKSPSVVLMSLEDYNAIMETAYLLRSPANAARLREALHAADAGKTVQH
DLED

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1K1LCT7

Antitoxin

Source ID Structure
AlphaFold DB B6WT68

References