Detailed information of TA system TA293395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09907-MazE
• Location: 2497320..2497921
• Replicon: chromosome
• Accession: NZ_LT630287
• Organism: Ligilactobacillus acidipiscis strain ACA-DC 1533

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: BQ5903_RS11585
• Protein ID: WP_056972590.1
• Coordinates: 2497320..2497664 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: BQ5903_RS11590
• Protein ID: WP_056972592.1
• Coordinates: 2497658..2497921 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BQ5903_RS11565	2492564..2494258	+	1695	WP_079579603.1	aryl-sulfate sulfotransferase	-
BQ5903_RS11570	2494417..2495124	+	708	WP_010495907.1	glucosamine-6-phosphate deaminase	-
BQ5903_RS11575	2495729..2496622	-	894	WP_079578748.1	IS982 family transposase	-
BQ5903_RS11580	2496730..2497176	+	447	Protein_2231	helicase	-
BQ5903_RS11585	2497320..2497664	-	345	WP_056972590.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BQ5903_RS11590	2497658..2497921	-	264	WP_056972592.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BQ5903_RS11595	2498017..2498604	+	588	WP_079579604.1	site-specific integrase	-
BQ5903_RS11600	2498617..2498976	+	360	WP_056972596.1	hypothetical protein	-
BQ5903_RS11605	2499102..2500487	-	1386	WP_079579685.1	group II intron reverse transcriptase/maturase	-
BQ5903_RS11610	2500987..2502117	-	1131	WP_079579605.1	NAD(P)-dependent alcohol dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-104)

Antitoxin

• Antitoxin PemI-like (8-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13111.00 Da
• Isoelectric Point: 6.8698

>T293395 WP_056972590.1 NZ_LT630287:c2497664-2497320 [Ligilactobacillus acidipiscis]
MVSQGDIFYVNFNPRRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Nucleotide

• Length: 345 bp

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10140.48 Da
• Isoelectric Point: 6.4690

>AT293395 WP_056972592.1 NZ_LT630287:c2497921-2497658 [Ligilactobacillus acidipiscis]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKNWQDDGKRDHELDWGKS
EGNELQW

Nucleotide

• Length: 264 bp