Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1572290..1572958 Replicon draft genome
Accession NC_021026
Organism Streptococcus pneumoniae SPN994038

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPN994038_RS08360 Protein ID WP_001132285.1
Coordinates 1572779..1572958 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag SPN994038_RS08355 Protein ID WP_000961812.1
Coordinates 1572290..1572742 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPN994038_RS08330 1568180..1568923 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPN994038_RS08335 1568925..1569875 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
SPN994038_RS08340 1570013..1570441 - 429 WP_000418157.1 NUDIX hydrolase -
SPN994038_RS08345 1570422..1571510 - 1089 WP_000719712.1 M50 family metallopeptidase -
SPN994038_RS08350 1571529..1571999 - 471 WP_000257088.1 DUF3013 family protein -
SPN994038_RS08355 1572290..1572742 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPN994038_RS08360 1572779..1572958 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPN994038_RS08365 1573095..1573343 - 249 WP_000797237.1 hypothetical protein -
SPN994038_RS08370 1573333..1573572 - 240 WP_000818079.1 hypothetical protein -
SPN994038_RS08375 1573842..1575113 + 1272 WP_001113213.1 replication-associated recombination protein A -
SPN994038_RS08385 1575533..1576660 - 1128 WP_000323403.1 site-specific integrase -
SPN994038_RS08390 1576662..1576844 - 183 WP_000655518.1 DUF3173 domain-containing protein -
SPN994038_RS08395 1576860..1577903 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T29339 WP_001132285.1 NC_021026:c1572958-1572779 [Streptococcus pneumoniae SPN994038]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T29339 NC_021026:c1572958-1572779 [Streptococcus pneumoniae SPN994038]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT29339 WP_000961812.1 NC_021026:c1572742-1572290 [Streptococcus pneumoniae SPN994038]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT29339 NC_021026:c1572742-1572290 [Streptococcus pneumoniae SPN994038]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGCTAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References