Detailed information of TA system TA029338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1108734..1109232
• Replicon: draft genome
• Accession: NC_021026
• Organism: Streptococcus pneumoniae SPN994038

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPN994038_RS05820
• Protein ID: WP_001812387.1
• Coordinates: 1108734..1108988 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: SPN994038_RS05825
• Protein ID: WP_000208080.1
• Coordinates: 1108990..1109232 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPN994038_RS05805	1103995..1106463	-	2469	WP_001152997.1	DNA gyrase subunit A	-
SPN994038_RS05810	1106657..1107643	+	987	WP_000204733.1	L-lactate dehydrogenase	-
SPN994038_RS05815	1107992..1108687	-	696	WP_000731127.1	potassium channel family protein	-
SPN994038_RS05820	1108734..1108988	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPN994038_RS05825	1108990..1109232	-	243	WP_000208080.1	hypothetical protein	Antitoxin
SPN994038_RS05830	1109323..1110132	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
SPN994038_RS05835	1110134..1111483	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
SPN994038_RS05840	1111476..1112180	-	705	WP_000722076.1	response regulator transcription factor	-
SPN994038_RS05845	1112235..1113410	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T29338 WP_001812387.1 NC_021026:c1108988-1108734 [Streptococcus pneumoniae SPN994038]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T29338 NC_021026:c1108988-1108734 [Streptococcus pneumoniae SPN994038]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT29338 WP_000208080.1 NC_021026:c1109232-1108990 [Streptococcus pneumoniae SPN994038]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT29338 NC_021026:c1109232-1108990 [Streptococcus pneumoniae SPN994038]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7